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ALPHA LIPOIC ACID
Score
Data: Fair
CAS62-46-4
facial moisturizer/ treatment (48 products)
anti-aging (40 products)
around-eye cream (12 products)
toners/ astringents (8 products)
facial cleanser (7 products)
Show all 106 products that contain ALPHA LIPOIC ACID.
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ALPHA LIPOIC ACID


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicity no information
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other LOW concerns: Data gaps

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Synonym(s): 5- (1,2-DITHIOLAN-3-YL) VALERIC ACID; 5- (1,2-DITHIOLAN-3-YL) VALERIC ACID; 6,8-DITHIOOCTANOIC ACID; 6,8-THIOCTIC ACID; 6,8-THIOTIC ACID; 6-THIOCTIC ACID; 6-THIOTIC ACID; ACETATE-REPLACING FACTOR; ALPHA-LIPOIC ACID; ALPHA-LIPONIC ACID; ALPHA-LIPONSAEURE (GERMAN)

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
3,682 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- Archives of Toxicology 1978ALPHA LIPOIC ACID• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Archives of Toxicology 2002ALPHA LIPOIC ACID• biochemical - Multiple enzyme effects (rat TDLo)
• kidney or renal system - Other changes (rat TDLo)
• biochemical - Other proteins (rat TDLo)
RTECS®- Arzneimittel-Forschung 1971ALPHA LIPOIC ACID• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Drugs in Japan (Ethical Drugs) 1982ALPHA LIPOIC ACID• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- European Journal of Clinical Pharmacology 1999ALPHA LIPOIC ACID• metabolic - Conditioned vitamin deficiency ( human TDLo)
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1990ALPHA LIPOIC ACID• blood - Change in clotting factors ( human TDLo)
RTECS®- Journal of Applied Toxicology (John Wiley & Sons, Ltd 2004ALPHA LIPOIC ACID• blood - Changes in serum composition (eg., TP, bilirubin, cholesterol) (rat TDLo)
• biochemical - Phosphatases (rat TDLo)
• biochemical - Transaminases (rat TDLo)
RTECS®- Journal of Diabetes and Its Complications (Elsevier) V 2004ALPHA LIPOIC ACID• gastrointestinal - Nausea or vomiting ( human TDLo)
• gastrointestinal - Other changes ( human TDLo)
RTECS®- Nippon Yakurigaku Zasshi 1964ALPHA LIPOIC ACID• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS®- Nippon Yakurigaku Zasshi 1972ALPHA LIPOIC ACID• reproductive - Prostate, seminal vesicle, Cowper's gland, accessory glands (rat TDLo)
• brain, nervous system, or behavioral effect - Convulsions or effect on seizure threshold (rat LD50)
• respiratory - Respiratory depression (rat LD50)
• brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (rat LD50)
RTECS®- Toxicology Letters 2005ALPHA LIPOIC ACID• biochemical - Lipids, including transport (rat TDLo)
• kidney or renal system - Other changes (rat TDLo)
RTECS®- Toxicology 2002ALPHA LIPOIC ACID• kidney or renal system - Other changes (rat TDLo)
• biochemical - Other enzymes (rat TDLo)
• biochemical - Other proteins (rat TDLo)
RTECS®- Toxicology 2005ALPHA LIPOIC ACID• biochemical - Multiple enzyme effects (rat TDLo)
RTECS®- Toxicology 2005ALPHA LIPOIC ACID• biochemical - Effect on mitochondrial function (rat TDLo)
• cardiovascular - Other changes (rat TDLo)
• biochemical - TCS cycle (rat TDLo)

references
government/industry list/academic study reference
RTECS®- Archives of Toxicology 1978 [shown for informational purposes only]RTECS®- Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- 41,79,1978
RTECS®- Archives of Toxicology 2002 [shown for informational purposes only]RTECS®- Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- 76,437,2002
RTECS®- Arzneimittel-Forschung 1971 [shown for informational purposes only]RTECS®- Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- 21,284,1971
RTECS®- Drugs in Japan (Ethical Drugs) 1982 [shown for informational purposes only]RTECS®- Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) 6,454,1982
RTECS®- European Journal of Clinical Pharmacology 1999 [shown for informational purposes only]RTECS®- European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970- (),A52,1999
RTECS®- Farmakologiya i Toksikologiya (Moscow) 1990 [shown for informational purposes only]RTECS®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 53,47,1990
RTECS®- Journal of Applied Toxicology (John Wiley & Sons, Ltd 2004 [shown for informational purposes only]RTECS®- Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- 24,21,2004
RTECS®- Journal of Diabetes and Its Complications (Elsevier) V 2004 [shown for informational purposes only]RTECS®- Journal of Diabetes and Its Complications (Elsevier) V.6- 1992- 18,79,2004
RTECS®- Nippon Yakurigaku Zasshi 1964 [shown for informational purposes only]RTECS®- Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- -1944 60,278,1964
RTECS®- Nippon Yakurigaku Zasshi 1972 [shown for informational purposes only]RTECS®- Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- -1944 68,265,1972
RTECS®- Toxicology Letters 2005 [shown for informational purposes only]RTECS®- Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- 160,1,2005
RTECS®- Toxicology 2002 [shown for informational purposes only]RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 177,187,2002
RTECS®- Toxicology 2005 [shown for informational purposes only]RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 210,25,2005
RTECS®- Toxicology 2005 [shown for informational purposes only]RTECS®- Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- 215,108,2005

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