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Score:
Data available:
 
Good

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ALCOHOL DENATURED


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
Allergies & immunotoxicity
 
 
Use restrictions
 
 
Other HIGH concerns: Multiple, additive exposure sources; Other MODERATE concerns: Organ system toxicity (non-reproductive); Other LOW concerns: Enhanced skin absorption, Data gaps, Occupational hazards

About ALCOHOL DENATURED: Denatured alcohol is a mixture of ethanol (ethyl alcohol) with a denaturing agent. Ethanol is considered broadly toxic and linked to birth defects following excessive oral ingestion. Potential risks f ... read more

Function(s): ANTIFOAMING; ANTIMICROBIAL; ASTRINGENT; MASKING; SOLVENT; VISCOSITY CONTROLLING

Synonym(s): ALCOHOL, COMPLETELY DENATURED; DENATURED ALCOHOL, DESIGNATED BY THE GOVERNMENT; DENATURED ALCOHOL, NOT DESIGNATED BY THE GOVERNMENT; DESIGNATED BY THE GOVERNMENT DENATURED ALCOHOL; NOT DESIGNATED BY THE GOVERNMENT DENATURED ALCOHOL

Multiple, additive exposure sources

Concern Reference
Used in food or as an additive with limited or no toxicity information availableFDA Everything Added to Food
Designated as safe for general or specific, limited use in foodFDA Food Additive Status

Developmental/reproductive toxicity

Concern Reference
Limited evidence of reproductive toxicityFrazier , L
Limited evidence of developmental toxicityJankovic, J

Cancer

Concern Reference
Cancer - limited evidenceA Relational Database of Hazardous Chemicals and Occupational Diseases

Organ system toxicity (non-reproductive)

Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Limited evidence of sense organ toxicityHarvell, J
Limited evidence of gastrointestinal or liver toxicityKlaassen, C

Occupational hazards

Concern Reference
Allowed workplace exposures restricted to high dosesNational Library of Medicine HazMap

Miscellaneous

Concern Reference
Occupational hazards related to handlingEuropean Union - Classification & Labelling

Enhanced skin absorption

Concern Reference
Penetration enhancerMutalik S, Udupa N

Data gaps

Concern Reference
Insufficient data to determine safetyCosmetic Ingredient Review Assessments
78,649 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html; National Toxicology Program. 10th Report on Carcinogens (2002). http://ehis.niehs.nih.gov/roc/toc10.html
AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Frazier , L. and M. L. Hage (eds.). Reproductive Hazards of the Workplace, Wiley Europe, 1998. Table 10 (Partial List of Reproductive Toxicants) available at http://www.pharmacy.ohio-state.edu/homepage/safety/chemhygiene_table_repro.pdf.
Harvell, J., M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Jankovic, J. A Screening Method for Occupational Reproductive Health Risk. American Industrial Hygiene Association Journal. 57: 641-649. 1996.
Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull
Mutalik S, Udupa N. "Effect of some penetration enhancers on the permeation of glibenclamide and glipizide through mouse skin." Pharmazie. 2003 Dec;58(12):891-4. ; Brand RM, Jendrzejewski JL, Henery EM, Charron AR. A single oral dose of ethanol can alter transdermal absorption of topically applied chemicals in rats. Toxicol Sci. 2006 Aug;92(2):349-55. Epub 2006 May 5.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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