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ACRYLAMIDE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
 
 
Use restrictions
 
 

Possible impurity in: POLYACRYLAMIDE (1,156 products), POLYQUATERNIUM-7 (987 products), POLYACRYLIC ACID (43 products), see all ingredients | products

Synonym(s): 2PROPENAMIDE; 2-PROPENAMIDE; 2-PROPENAMIDE (9CI) ; ACRYLAMIDE (ACGIH:OSHA) ; ACRYLAMIDE MONOMER; ACRYLIC AMIDE; AKRYLAMID (CZECH) ; AMID KYSELINY AKRYLOVE (CZECH) ; ETHYLENECARBOXAMIDE; PROPENAMIDE; PROPENOIC ACID AMIDE

Cancer

Concern Reference
Possible human carcinogenEuropean Union - Classification & Labelling
Possible human carcinogenEPA Integrated Risk Information System (IRIS)
Possible human carcinogenInt'l Agency for Research on Cancer (IARC) - Carcinogens
Possible human carcinogenNTP Report on Carcinogens, 11th Edition
Possible human carcinogenCalifornia EPA Proposition 65
Limited evidence of carcinogenicityAmer Conf of Gov't Industrial Hygienists - Carcinogens
Limited evidence of carcinogenicityNIOSH Occupational Carcinogens
Possible mutagenEuropean Union - Classification & Labelling
Cancer - limited evidenceSilent Spring's Mammary Carcinogens Reviews Database

Organ system toxicity (non-reproductive)

Concern Reference
Known human respiratory toxicantEPA Hazardous Air Pollutants
Classified as a high human health priorityEnvironment Canada Domestic Substance List
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as toxic or harmful (only for products for use around the mouth; products for use on the lips)European Union - Classification & Labelling
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap

Developmental/reproductive toxicity

Concern Reference
Limited evidence of developmental toxicityEuropean Union - Classification & Labelling
Limited evidence of reproductive toxicityNational Library of Medicine HazMap
Limited evidence of reproductive toxicityUS EPA

Allergies/immunotoxicity

Concern Reference
Limited evidence of immune system toxicity or allergies (only for products for use on skin)European Union - Classification & Labelling
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Occupational hazards

Concern Reference
Allowed workplace exposures restricted to low dosesEuropean Union - Classification & Labelling

Irritation (skin, eyes, or lungs)

Concern Reference
Classified as irritantEuropean Union - Classification & Labelling

Ecotoxicology

Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Neurotoxicity

Concern Reference
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
8,217 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Data Sources

ACGIH (American Conference of Governmental Industrial Hygienists) 2008. ACGIH cancer classification system. www.acgih.org.
AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
NIOSH (National Institute for Occupational Safety and Health). 2006. NIOSH Carcinogens List (Potential occupational carcinogens). http://www.cdc.gov/niosh/npotocca.html.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
NTP (National Toxicology Program). 2006. NTP Center for the Evaluation fo Risks to Human Reproduction (CERHR). NTP-CERHR Reports and Monographs.
Rudel RA, KR Attfield, JN Schifano and JG Brody. Chemicals Causing Mammary Gland Tumors in Animals Signal New Directions for Epidemiology, Chemicals Testing, and Risk Assessment for Breast Cancer Prevention. CANCER Supplement. 2007 Jun 15;109(12):2635-2666.
US EPA. Roadmaps to Sources of Information on Chemicals Listed in the Emergency Planning Community and Community Right-to-Know Act (Also Known as SARA Title 3), Section 313 Toxic Release Inventory (for Microcomputers). (Report Number EPADFDK92040). 1991. Data file distributed in 2 diskettes by Office of Pollution, Prevention, and Toxics, Environmental Protection Agency, Washington, DC. NOTE: Datasource no longer being maintained by EPA; not currently available online., Frazier , L. and M. L. Hage (eds.). Reproductive Hazards of the Workplace, Wiley Europe, 1998. Table 10 (Partial List of Reproductive Toxicants) available at http://www.pharmacy.ohio-state.edu/homepage/safety/chemhygiene_table_repro.pdf., Jankovic, J. A Screening Method for Occupational Reproductive Health Risk. American Industrial Hygiene Association Journal. 57: 641-649. 1996., Chapin, R.E. and R.A. Sloane. NIEHS/NTP Reproductive Assessment by Continuous Breeding: Evolving Study Design and Summaries of Ninety Studies. Environmental Health Perspectives 105, Supplement 1: 199-394. 1997. http://ehpnet1.niehs.nih.gov/docs/1997/Suppl-1/chapin.html

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer