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Score:
Data available:
 
Fair

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ACETONE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
Developmental &
reproductive toxicity
 
 
Allergies & immunotoxicity
 
 
Use restrictions
 
 
Other HIGH concerns: Irritation (skin, eyes, or lungs), Organ system toxicity (non-reproductive); Other MODERATE concerns: Neurotoxicity; Other LOW concerns: Occupational hazards

About ACETONE: Acetone is an aliphatic ketone.

Function(s): Denaturant; Fragrance Ingredient; Solvent

Synonym(s): 2-PROPANONE; DIMETHYL KETONE; DIMETHYLFORMALDEHYDE; METHYL KETONE; 2-PROPANONE; ACETON (GERMAN, DUTCH, POLISH) ; ACETONE (ACGIH:OSHA) ; BETA-KETOPROPANE; CHEVRON ACETONE; DIMETHYL KETONE; DIMETHYLFORMALDEHYDE

Neurotoxicity

Concern Reference
Moderate evidence of human neurotoxicityThreshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH) 2012
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyNational Library of Medicine HazMap

Organ system toxicity (non-reproductive)

Concern Reference
Known human respiratory irritant toxicantToxicological profile for Acetone
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as medium human health priorityEnvironment Canada Domestic Substance List
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs

Irritation (skin, eyes, or lungs)

Concern Reference
Classified as irritantEuropean Union - Classification & Labelling
Human eye irritant - strong evidenceEuropean Union Globally Harmonized System- Classification & Labelling Codes

Cancer

Concern Reference
Not likely to be carcinogenic in humansEPA Water Disinfection By-Products Carcinogenicity

Miscellaneous

Concern Reference
Occupational hazards related to handlingEuropean Union - Classification & Labelling

Multiple, additive exposure sources

Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Persistence and bioaccumulation

Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data gaps

Concern Reference
20,552 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data Sources

AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
Agency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull
CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
EPA (U.S. Environmental Protection Agency). 2006. EPA Water Disinfection By-Products with Carcinogenicity Estimates. Last updated: 10 April 2006.
EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
European Union Globally Harmonized System- Classification & Labelling Codes. 2012.
FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH) 2012.
Toxicological profile for Acetone. U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry. 1994.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer