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ACETONE
Score
Data: Good
CAS67-64-1
polish remover (23 products)
nail polish (13 products)
muscle/ joint soreness (4 products)
pain relief (4 products)
facial moisturizer/ treatment (3 products)
Show all 52 products that contain ACETONE.
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ACETONE


image source: PubChem
Health concerns of ingredient
About the ratings
Cancer no information
Developmental & reproductive toxicityyes
Allergies & immunotoxicity no information
Use restrictions no information
Contamination concerns: none
Other HIGH concerns: Irritation (skin, eyes, or lungs)
Other MODERATE concerns: Neurotoxicity, Organ system toxicity (non-reproductive)
Other LOW concerns: Data gaps, Occupational hazards

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

Function/use(s): Denaturant; Fragrance Ingredient; Solvent

About ACETONE: Acetone is an aliphatic ketone.

Synonym(s): DIMETHYLFORMALDEHYDE; DIMETHYL KETONE; METHYL KETONE; 2-PROPANONE; 2-PROPANONE; ACETON (GERMAN, DUTCH, POLISH) ; ACETONE (ACGIH:OSHA) ; BETA-KETOPROPANE; CHEVRON ACETONE; DIMETHYL KETONE; DIMETHYLFORMALDEHYDE

Neurotoxicity

type of concern product conditions reference
Strong evidence of human neurotoxicity    Chemicals known to be neurotoxic to humans
show more

Developmental/reproductive toxicity

type of concern product conditions reference
Human nervous system toxicant - moderate evidence    Chemicals known to be neurotoxic to humans
show more

Organ system toxicity (non-reproductive)

type of concern product conditions reference
Possible human cardiovascular toxicant    CHE Toxicant and Disease Database
Classified as expected to be toxic or harmful    Environment Canada Domestic Substance List
Classified as medium human health priority    Environment Canada Domestic Substance List
show more

Irritation (skin, eyes, or lungs)

type of concern product conditions reference
Classified as irritant    European Union - Classification & Labelling

Data gaps

type of concern product conditions reference
Not assessed for safety in cosmetics by industry panel  
18,780 studies in PubMed science library may include information on the toxicity of this chemical see search results ->   PubMed

Ecotoxicology

type of concern product conditions reference
Not suspected to be an environmental toxin    Environment Canada Domestic Substance List

Multiple, additive exposure sources

type of concern product conditions reference
Designated as safe for general or specific, limited use in food   FDA Food Additive Status
Designated as safe for general or specific, limited use in food   FDA Everything Added to Food

Cancer

type of concern product conditions reference
Not likely to be carcinogenic in humans    EPA Water Disinfection By-Products Carcinogenicity

Miscellaneous

type of concern product conditions reference
Occupational hazards related to handling   European Union - Classification & Labelling

Persistence and bioaccumulation

type of concern product conditions reference
Not suspected to be bioaccumulative    Environment Canada Domestic Substance List

Government, industry, academic studies and classifications
government/industry list/academic study appears on list as classification(s)
European Union - Classification & LabellingACETONE;;PROPAN-2-ONE; PROPANONEF; R11;Xi; R36 R66 R67
FDA Food Additive StatusACETONE• SOLV
• REG
• 30 ppm - As residual solvent in spice oleoresins 173.210
Association of Occupational and Environmental ClinicsACETONE• S
Association of Occupational and Environmental ClinicsACETONE• S
Association of Occupational and Environmental ClinicsACETONE• S
CHE Toxicant and Disease DatabaseACETONEAbnormal sperm (morphology, motility, and sperm count) - Limited
CHE Toxicant and Disease DatabaseACETONEArrhythmias - Good
EPA Water Disinfection By-Products CarcinogenicityACETONELow
FDA Everything Added to FoodACETONE• ASP
EPA Integrated Risk Information System (IRIS)ACETONEData are inadequate for an assessment of human carcinogenic potential
National Library of Medicine HazMapACETONESD: No;NT: CNS Solvent Syndrome;PE: 1000 ppm;ST: 750 ppm;RD: 23480 ppm;LC: 51755 ppm;TL: 500 ppm;BE: Acetone in urine = 50 mg/L; end of shift;;FL: 3: may ignite at ambient temperature;ID: 2500 ppm;OH: 653 ppm;OL: 3.6 ppm;MA: 500 ppm;
Chemicals known to be neurotoxic to humansACETONEknown to be neurotoxic to humans
EPA Toxic Release Inventory PBTsACETONEToxic under the EPA's Toxics Release Inventory
Agency for Toxic Substances and Disease Registry, 2004ACETONECardiovascular or Blood Toxicity Hazards: suspected
Environment Canada Domestic Substance List2-PROPANONEY-Categorization,Y-Human health,Moderate-Health Priority,Y-Persistent,,,,,,
IFRA Fragrance Ingredient List2-PROPANONEreported as used in fragrance compounds in 2008

Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as classification(s)
RTECS®- TLV/BEI,2006ACETONE• occupationally related - ACGIH TLV (human TWA)
RTECS®- TLV/BEI,2007ACETONE• occupationally related - ACGIH TLV (human TWA)
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986ACETONE• sense organ - Primary eye irritant (rabbit )
• skin - Primary skin irritant (rabbit )
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994ACETONE• mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (mouse ihl)
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994ACETONE• mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (mouse ihl)
RTECS®- American Journal of Ophthalmology 1946ACETONE• sense organ - Primary eye irritant (rabbit )
RTECS®- Annals of the New York Academy of Sciences 1983ACETONE• mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (Saccharomyces cerevisiae )
RTECS®- Annals of the New York Academy of Sciences 1983ACETONE• mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (Saccharomyces cerevisiae )
RTECS®- CRC Critical Reviews in Toxicology 2002ACETONE• sense organ - Primary eye irritant ( human )
RTECS®- CRC Critical Reviews in Toxicology 2002ACETONE• sense organ - Primary eye irritant ( human )
RTECS®- Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 -,27,2005ACETONE• sense organ - Primary eye irritant (rabbit )
RTECS®- Food and Chemical Toxicology 1984ACETONE• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr)
RTECS®- Food and Chemical Toxicology 1984ACETONE• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr)
RTECS®- Journal of Industrial Hygiene and Toxicology 1943ACETONE• sense organ - Primary eye irritant ( human )
RTECS®- Journal of Toxicologic Pathology 2001ACETONE• sense organ - Primary eye irritant (rabbit )
RTECS®- Journal of Toxicologic Pathology 2001ACETONE• sense organ - Primary eye irritant (rabbit )
RTECS®- MSHA STANDARD-air: 3,3,1971ACETONE• occupationally related - MSHA STANDARD-air (human TWA)
RTECS®- National Technical Information Service 5975ACETONE• reproductive - Spermatogenesis (rat TDLo)
RTECS®- National Toxicology Program Technical Report Series 3122ACETONE• kidney or renal system - Changes in bladder weight (rat TDLo)
• liver - Changes in liver weight (rat TDLo)
• blood - Normocytic anemia (rat TDLo)
RTECS®- OSHA PEL (Construc): 29,1926 1994ACETONE• occupationally related - OSHA PEL (Construc) (human TWA)
RTECS®- OSHA PEL (Fed Cont): 41,50-204 1994ACETONE• occupationally related - OSHA PEL (Fed Cont) (human TWA)
RTECS®- OSHA PEL (Gen Indu): 29,1910 1994ACETONE• occupationally related - OSHA PEL (Gen Indu) (human TWA)
RTECS®- OSHA PEL (Shipyard): 29,1915 1993ACETONE• occupationally related - OSHA PEL (Shipyard) (human TWA)
RTECS®- Union Carbide Data Sheet 1970ACETONE• skin - Primary skin irritant (rabbit )

references
government/industry list/academic study reference
European Union - Classification & LabellingCPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
FDA Food Additive StatusFDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
Association of Occupational and Environmental ClinicsAOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation.
CHE Toxicant and Disease DatabaseCHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database.
EPA Water Disinfection By-Products CarcinogenicityEPA (U.S. Environmental Protection Agency). 2006. EPA Water Disinfection By-Products with Carcinogenicity Estimates. Last updated: 10 April 2006.
FDA Everything Added to FoodFDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
EPA Integrated Risk Information System (IRIS)EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
National Library of Medicine HazMapNLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
Chemicals known to be neurotoxic to humansGrandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78.
EPA Toxic Release Inventory PBTsEPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
Scorecard.org Toxicity InformationAgency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996.
Environment Canada Domestic Substance ListEC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient ListIFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
RTECS®- TLV/BEI,2006 [shown for informational purposes only]RTECS®- TLV/BEI,2006
RTECS®- TLV/BEI,2007 [shown for informational purposes only]RTECS®- TLV/BEI,2007
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 [shown for informational purposes only]RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,280,1986
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 [shown for informational purposes only]RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,409,1994
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 [shown for informational purposes only]RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. -,409,1994
RTECS®- American Journal of Ophthalmology 1946 [shown for informational purposes only]RTECS®- American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- 29,1363,1946
RTECS®- Annals of the New York Academy of Sciences 1983 [shown for informational purposes only]RTECS®- Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- 407,186,1983
RTECS®- Annals of the New York Academy of Sciences 1983 [shown for informational purposes only]RTECS®- Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 407,186,1983
RTECS®- CRC Critical Reviews in Toxicology 2002 [shown for informational purposes only]RTECS®- CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 32,43,2002
RTECS®- CRC Critical Reviews in Toxicology 2002 [shown for informational purposes only]RTECS®- CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- 32,43,2002
RTECS®- Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 -,27,2005 [shown for informational purposes only]RTECS®- Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 -,27,2005
RTECS®- Food and Chemical Toxicology 1984 [shown for informational purposes only]RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 22,623,1984
RTECS®- Food and Chemical Toxicology 1984 [shown for informational purposes only]RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 22,623,1984
RTECS®- Journal of Industrial Hygiene and Toxicology 1943 [shown for informational purposes only]RTECS®- Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. 25,282,1943
RTECS®- Journal of Toxicologic Pathology 2001 [shown for informational purposes only]RTECS®- Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988 29,187,2001
RTECS®- Journal of Toxicologic Pathology 2001 [shown for informational purposes only]RTECS®- Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 29,187,2001
RTECS®- MSHA STANDARD-air: 3,3,1971 [shown for informational purposes only]RTECS®- MSHA STANDARD-air: 3,3,1971
RTECS®- National Technical Information Service 5975 [shown for informational purposes only]RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB91-185975
RTECS®- National Toxicology Program Technical Report Series 3122 [shown for informational purposes only]RTECS®- National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- NIH-91-3122
RTECS®- OSHA PEL (Construc): 29,1926 1994 [shown for informational purposes only]RTECS®- OSHA PEL (Construc): 29,1926.55,1994
RTECS®- OSHA PEL (Fed Cont): 41,50-204 1994 [shown for informational purposes only]RTECS®- OSHA PEL (Fed Cont): 41,50-204.50,1994
RTECS®- OSHA PEL (Gen Indu): 29,1910 1994 [shown for informational purposes only]RTECS®- OSHA PEL (Gen Indu): 29,1910.1000,1994
RTECS®- OSHA PEL (Shipyard): 29,1915 1993 [shown for informational purposes only]RTECS®- OSHA PEL (Shipyard): 29,1915.1000,1993
RTECS®- Union Carbide Data Sheet 1970 [shown for informational purposes only]RTECS®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 5/7/1970

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