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5-BROMO-5-NITRO-1,3 DIOXANE (FORMALDEHYDE RELEASER)


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
 
Other HIGH concerns: Chemical release concerns; Other LOW concerns: Data gaps

About 5-BROMO-5-NITRO-1,3 DIOXANE (FORMALDEHYDE RELEASER): 5-Bromo-5-Nitro-1, 3-Dioxane is a substituted cyclic ether.

Function(s): Preservative

Synoym(s): 5-BROMO-5-NITRO-1,3-DIOXANE, 1,3-DIOXANE, 5-BROMO-5-NITRO-; 1,3DIOXANE, 5BROMO5NITRO; 5-BROMO-5-NITRO- 1,3-DIOXANE; 5-BROMO-5-NITRO-1,3 DIOXANE; 1,3-DIOXANE, 5-BROMO-5-NITRO-; 5-BROM-5-NITRO-1,3-DIOXAN (GERMAN) ; 5-BROMO-5-NITRO-M-DIOXANE; BRONIDOX

Allergies/immunotoxicity

Concern Reference
Known human toxicant or allergen
Human skin toxicant or allergen - strong evidenceCosmetic Ingredient Review Assessments
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap
One or more animal studies show or allergenic effects at moderate dosesDe Groot AC

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsCosmetic Ingredient Review Assessments

Cancer

Concern Reference
Cancer - limited evidenceIARC (International Agency for Research on Cancer)

Data gaps

Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
8 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Chemical release concerns

Chemical Score
FORMALDEHYDE
Data: Fair
NITROSAMINES
Data: Fair

Data Sources

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
De Groot AC. 2010. Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Contact Dermatitis, 62: 2–17.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Formaldehyde - Global Harmonized System (GHS)
Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99.
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer