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4-METHYLBENZYLIDENE CAMPHOR


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
 
Allergies & immunotoxicity
 
 

About 4-METHYLBENZYLIDENE CAMPHOR: A UV filter not approved as an active ingredient for sunscreen in the U.S., but listed as an inactive ingredient in some products. European researchers cite concerns over thyroid toxicity, hormone dis ... read more

Function(s): Ultraviolet Light Absorber; UV ABSORBER; UV FILTER

Synonym(s): (±) -1,7,7-TRIMETHYL-3- [ (4-METHYLPHENYL) METHYLENE] BICYCLO [2.2.1] HEPTAN-2-ONE; 1,7,7-TRIMETHYL-3- [ (4-METHYLPHENYL) METHYLENE] - BICYCLO [2.2.1] HEPTAN-2-ONE; 1,7,7-TRIMETHYL-3- [ (4-METHYLPHENYL) METHYLENE] BICYCLO [2.2.1] HEPTAN-2-ONE; 3- (4-METHYLBENZYLIDENE) -DL-CAMPHOR; 4-METHYL-3-BENZYLIDINE CAMPHOR; 4-METHYLBENZYLIDINE CAMPHOR; 4MBC; BICYCLO (2.2.1) HEPTAN-2-ONE, 1,7,7-TRIMETHYL-3- [ (4-METHYLPHENYL) METHYLENE] -; BICYCLO [2.2.1] HEPTAN-2-ONE, 1,7,7-TRIMETHYL-3- [ (4-METHYLPHENYL) METHYLENE] -; ENACAMENE; EUSOLEX 6300

Use restrictions

Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - SCCP (2006)

Endocrine disruption

Concern Reference
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
Limited evidence of disruption
Limited evidence of endocrine disruption
Associated with endocrine disruptionDurrer S, Ehnes C, Fuetsch M et al

Developmental/reproductive toxicity

Concern Reference
One or more animal studies show effects at very low dosesDurrer S, Ehnes C, Fuetsch M et al
One or more animal studies show developmental effects at low dosesSchlumpf M, Durrer S, Faass O et al
Limited evidence of developmental toxicity

Persistence and bioaccumulation

Concern Reference
Persistent, bioaccumulative in wildlifeOSPAR PBTs - Substances of Possible Concern
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature
Ingredient is suspected or measured to accumulate in peopleSchlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al
Not suspected to be persistentEnvironment Canada Domestic Substance List

Enhanced skin absorption

Concern Reference
Absorbs into the skinSCCP (2006)
Absorbs into the skinKlinubol P, Asawanonda P, Wanichwecharungruang SP

Data gaps

Concern Reference
4,773 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data Sources

Durrer S, Ehnes C, Fuetsch M et al. "Estrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor." Environ Health Perspect 2007; 115 Suppl 1:42-50.
Durrer S, Ehnes C, Fuetsch M et al. "Estrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor." Environ Health Perspect 2007; 115 Suppl 1:42-50.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
Emerging PBTs from peer-reviewed literature
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Klinubol P, Asawanonda P, Wanichwecharungruang SP. Transdermal penetration of UV filters. Skin Pharmacol Physiol 2008; 21 (1):23-9.
Klinubol P, Asawanonda P, Wanichwecharungruang SP. Transdermal penetration of UV filters. Skin Pharmacol Physiol 2008; 21 (1):23-9.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
OSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
SCCP (2006). "Opinion concerning 4-Methylbenzylidene Camphor ". European Commission - The Scientfic Committee on Cosmetic Products and Non-Food Products Intended for Consumers. SCCP/1042/06 Retrieved from http://ec.europa.eu/health/ph_risk/committees/04_sccp/sccp_opinions_en.htm.
SCCP (2006). "Opinion concerning 4-Methylbenzylidene Camphor ". European Commission - The Scientfic Committee on Cosmetic Products and Non-Food Products Intended for Consumers. SCCP/1042/06 Retrieved from http://ec.europa.eu/health/ph_risk/committees/04_sccp/sccp_opinions_en.htm.
Schlumpf M, Durrer S, Faass O et al. "Developmental toxicity of UV filters and environmental exposure: a review." Int J Androl 2008; 31 (2):144-51.
Schlumpf M, Kypke K, Vökt C, Birchler M, Durrer S, Faass O, et al. 2008. Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk. Chimia 62: 1-7.
{Inui, 2003}
{SCCPNFP, 04; Gleich, 1988}
{SCCPNFP, 04}

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