Health Concerns of the Ingredient:
Overall Hazard
Developmental &
reproductive toxicity
Allergies & immunotoxicity
Function(s): Fragrance Ingredient; MASKING; PERFUMING
Synoym(s): HEXAMETHYLINDANOPYRAN, GALAXOLIDE (HHCB) ; HEXAHYDROHEXAMETHYL CYCLOPENTABENZOPYRAN; ABBALIDE; GALAXOLIDE 50; GALOXOLIDE; HHCB; PEARLIDE
Persistence and bioaccumulation
| Concern |
Reference |
|---|
| Persistent, bioaccumulative in wildlife | Emerging PBTs from peer-reviewed literature |
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Endocrine disruption
| Concern |
Reference |
|---|
| Associated with endocrine disruption | Seinen W, Lemmen JG, Pieters RH, Verbruggen EM, VanderBurg B |
| Associated with endocrine disruption | Schreurs RH, Quaedackers ME, Seinen W, van der Burg B |
| Associated with endocrine disruption | Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B |
Ecotoxicology
| Concern |
Reference |
|---|
| Wildlife and environmental toxicity | European Union - Classification & Labelling |
| Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern |
Reference |
|---|
| 239 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | NLM PubMed |
Organ system toxicity (non-reproductive)
| Concern |
Reference |
|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Data Sources
| CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. |
| EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998. |
| Emerging PBTs from peer-reviewed literature |
| IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov. |
| Schreurs RH, Quaedackers ME, Seinen W, van der Burg B. 2002. Transcriptional activation of estrogen receptor ERalpha and ERbeta by polycyclic musks is cell type dependent. Toxicol Appl Pharmacol. 183(1): 1-9. |
| Schreurs RH, Sonneveld E, Jansen JH, Seinen W, van der Burg B. 2005. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 83(2): 264-72. |
| Seinen W, Lemmen JG, Pieters RH, Verbruggen EM, VanderBurg B. 1999. AHTN and HHCB show weak estrogenic – but no uterotrophic activity. Toxicol. Lett. 111(1-2): 161–168. |
Products Containing the Ingredient
About the ratings
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.
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