ewg.org | About SkinDeep®/Methodology | Terms & Conditions | Build Your Own Report | FAQ
 
Score:
Data available:
 
Fair

Time is running out!

Donate before December 31
And your tax-deductible gift will be matched!

Sign Up!

TRICLOCARBAN


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
Cancer
 
 
 
Allergies & immunotoxicity
 
 
Other HIGH concerns: Persistence and bioaccumulation; Other MODERATE concerns: Organ system toxicity (non-reproductive); Other LOW concerns: Ecotoxicology, Endocrine disruption

About TRICLOCARBAN: Triclocarban is a substituted carbanilide.

Function(s): Cosmetic Biocide; Deodorant Agent; Preservative

Synonym(s): 3,4,4'-TRICHLOROCARBANILIDE; N- (4-CHLOROPHENYL) -N'- (3,4-DICHLOROPHENYL) - UREA; N- (4-CHLOROPHENYL) -N'- (3,4-DICHLOROPHENYL) UREA; TCC; TRICHLOROCARBANILIDE; UREA, N- (4-CHLOROPHENYL) -N'- (3,4-DICHLOROPHENYL) -; 3,4,4'-TRICHLOROCARBANILIDE; 3,4,4'-TRICHLORODIPHENYLUREA; CUSITER; CUTISAN; ENT 26925

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - CosIng
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - European Union Cosmetics Directive

Organ system toxicity (non-reproductive)

Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
One or more animal studies show blood and liver effects at moderate doses (low dose studies may be unavailable for this ingredient)Monsanto

Persistence and bioaccumulation

Concern Reference
Persistent, bioaccumulative in wildlifeOSPAR PBTs - Substances of Possible Concern
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

Concern Reference
One or more animal studies show reproductive effects at high dosesChen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL

Endocrine disruption

Concern Reference
Associated with endocrine disruptionChen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL

Ecotoxicology

Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Enhanced skin absorption

Concern Reference
Absorbs into the skinWester RC, Maibach HI, Surinchak J, Bucks DAW

Data gaps

Concern Reference
3,752 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Data Sources

Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL. Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar;149(3):1173-9.
Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL. Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar;149(3):1173-9.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
European Union Cosmetics Directive.
Monsanto. A twenty-four month dietary toxicity/carcinogenicity study of Triclocarban in rats. 1981. Report no. BDN-77-280.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
OSPAR (Oslo-Paris). 2002. OSPAR List of Substances of Possible Concern. Secondary OSPAR List of Substances of Possible Concern. Secondary OSPAR. Place Published, OSPAR Convention for the Protection of the Marine Environement of North-East Atlanic.
Wester RC, Maibach HI, Surinchak J, Bucks DAW. Predictability of in vitro diffusion systems: Effect of skin types and ages on percutaneous absorption of Triclocarban. Dermatol. 1985; 6:223-6.

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer