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ENSULIZOLE


image source: PubChem
Health Concerns of the Ingredient:
Overall Hazard
 
 
 
 
Developmental &
reproductive toxicity
 
 
Allergies & immunotoxicity
 
 

About ENSULIZOLE: Known to produce free radicals when exposed to sunlight, leading to damage of DNA, this UVB protector may have the potential to cause cancer.

Function(s): Sunscreen Agent; Ultraviolet Light Absorber; UV ABSORBER; UV FILTER

Synoym(s): PHENYLBENZIMIDAZOLE SULFONIC ACID, 1H-BENZIMIDAZOLE-5-SULFONIC ACID, 2-PHENYL-; 1HBENZIMIDAZOLE5SULFONIC ACID, 2PHENYL; 2-PHENYL-1H-BENZIMIDAZOLE-5-SULPHONIC ACID; 2-PHENYL-5-SULFOBENZIMIDAZOLE; 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID; EINECS 248-502-0; ENSULIZOLE (PHENYLBENZIMIDAZOLE SULFONIC ACID) ; PBSA

Use restrictions

Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - prohibited for use in some types of cosmeticsJapan's Standards for Cosmetics
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - SCCP

Biochemical or cellular level changes

Concern Reference
Produces excess reactive oxygen species that can interfere with cellular signaling, cause mutations, lead to cell death and may be implicated in cardiovascular disease.

Cancer

Concern Reference
One or more in vitro tests on mammalian cells show positive mutation results

Irritation (skin, eyes, or lungs)

Concern Reference
Not likely to be a skin irritant in humansSCCP

Data gaps

Concern Reference
345 studies in PubMed science library may include information on the toxicity of this chemical see search results ->NLM PubMed

Persistence and bioaccumulation

Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data Sources

EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
SCCP. 2006. Opinion concerning phenylbenzimidazole sufonic acid and its salts. Opinion: European Commission - The Scientfic Committee on Cosmetic Products and Non-Food Products Intended for Consumers. Available: http://ec.europa.eu/health/ph_risk/committees/04_sccp/sccp_opinions_en.htm
SCCP. 2006. Opinion concerning phenylbenzimidazole sufonic acid and its salts. Opinion: European Commission - The Scientfic Committee on Cosmetic Products and Non-Food Products Intended for Consumers. Available: http://ec.europa.eu/health/ph_risk/committees/04_sccp/sccp_opinions_en.htm
{Inbaraj, 2002}
{Serpone, 2002}
{Stevenson, 1999}
{Stevenson, 1999}

About the ratings

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer