Health Concerns of the Ingredient:
Overall Hazard
Developmental &
reproductive toxicity
About 2-BROMO-2-NITROPROPANE-1,3-DIOL: 2-Bromo-2-Nitropropane-1, 3-Diol is a substituted aliphatic diol.
Function(s): Preservative
Synoym(s): 1,3-PROPANEDIOL, 2-BROMO-2-NITRO-; 1,3PROPANEDIOL, 2BROMO2NITRO; 2-BROMO-2-NITRO- 1,3-PROPANEDIOL; BRONOPOL; 2-BROMO-2-NITRO-1,3-PROPANEDIOL; 2-BROMO-2-NITROPROPAN-1,3-DIOL; 2-BRONOPOL; BETA-BROMO-BETA-NITROTRIMETHYLENEGLYCOL; BRONIDIOL; BRONOCOT; BRONOPOL
Allergies/immunotoxicity
| Concern |
Reference |
|---|
| Human skin toxicant or allergen - strong evidence | |
| Limited evidence of immune system toxicity or allergies | National Library of Medicine HazMap |
Organ system toxicity (non-reproductive)
| Concern |
Reference |
|---|
| Known human lung and skin toxicant (only for products that may be aerosolized (airborne); products for use on skin) | European Union - Classification & Labelling |
| Limited evidence of gastrointestinal or liver toxicity | US EPA |
| Limited evidence of sense organ toxicity | A Relational Database of Hazardous Chemicals and Occupational Diseases |
| One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient) | EPA Toxic Release Inventory PBTs |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Occupational hazards
| Concern |
Reference |
|---|
| Allowed workplace exposures restricted to low doses | European Union - Classification & Labelling |
Irritation (skin, eyes, or lungs)
| Concern |
Reference |
|---|
| Classified as lung and skin irritant (only for products that may be aerosolized (airborne); products for use on skin) | European Union - Classification & Labelling |
Use restrictions
| Concern |
Reference |
|---|
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Ecotoxicology
| Concern |
Reference |
|---|
| Wildlife and environmental toxicity | European Union - Classification & Labelling |
| Suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern |
Reference |
|---|
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments |
| 141 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | NLM PubMed |
Persistence and bioaccumulation
| Concern |
Reference |
|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
| A Relational Database of Hazardous Chemicals and Occupational Diseases. Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html - testing a change |
| CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. |
| EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule. |
| European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ . |
| Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007. |
| NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
| NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov. |
| US EPA. Addition of Certain Chemicals; Toxic Chemical Release Reporting; Community Right to Know. Proposed and Final Rules. 59 Federal Register 1788 (Jan 12, 1994); 59 Federal Register 61432 (November 30, 1994). Summarized in Hazard Information on Toxic Chemicals Added to EPCRA Section 313 Under Chemical Expansion. http://www.epa.gov/tri/chemical/hazard_cx.htm |
Products Containing the Ingredient
About the ratings
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.
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