chemical Class
Volatile and semivolatile organic compounds (VOCs and SVOCs)
Chemicals in the class:
(1,1-dimethylbutyl) Oxirane, (1,2-dimethylbutyl)-Cyclohexane, (3-octylundecyl)-Benzene, (E)-3-Eicosene, (E)-3-Octadecene, (Z)-3-Hexadecene, (Z)-9,17-Octadecadienal, 1,5,5-trimethyl-6-(2-propenylidene)-Cyclohexene, 1,5-Heptadien-3-yne, 1,E-11,Z-13-Hexadecatriene, 1-(3-ethyloxiranyl)-Ethanone, 1-(trimethyloxiranyl)-Ethanone, 1-Heneicosyl formate, 1-Tetradecanol, 1-ethyl-1-methyl-Cyclopentane, 1-hexyl-3-methyl-Cyclopentane, 1-methyl-2-propyl-Cyclopentane, 1-methyl-Cyclopentanol, 11,14-Methyl Ester Eicosadienoic acid, 17-Pentatriacontene, 2,2,3,3-Tetramethylhexane, 2,2,4-trimethyl-Oxepane, 2,4,4-Trimethylhexane, 2,4,6-trimethyl-Decane, 2,4-Dimethylheptane, 2,4-Octanedione, 2,4-bis(1,1-dimethylethyl)-6-methyl-Phenol, 2,5,6-trimethyl-Decane, 2,5-Dimethyltetrahydrofuran, 2,6-dimethyl Heptadecane, 2-Decanol, 2-Hexanone, 2-Nonanone, 2-ethylhexyl glycidyl ether, 2-hydroxy-Cyclopentadecanone, 2-propenylidene-Cyclobutene, 3,4-dimethyl-4-Hexen-2-one, 3,7,11,15-tetramethyl-2-Hexadecene, 3-Methylcyclopentanol, 3-bromo-3-methyl Pentane, 3-bromo-Decane, 3-ethyl-2-methylhexane, 3-isopentyl Sydnone, 4,6-dimethyl-5-Hepten-2-one, 5,6-dimethyl-Decane, 5-Methyl-2-heptanol, 5-propyl-Tridecane, 6-ethyl-2-methyl-Decane, 7-methyl-7-Heptadecanol, 9-Hexadecenoic acid, Cetylpyridinium chloride monohydrate, Cyclohexane, Didodecyl 3,3-thiodipropionate, Diisooctyl ester Diphosphoric acid, Ethyl Benzene, Ethylcyclohexane, Hexacosane, Methyl ester 9,12-Hexadecadienoic acid, Methyl isobutyl carbinol, Mono(2-ethylhexyl) adipate, O-methyloxime 3,5-dimethyl-2-Cyclohexen-1-one, Octadecanal, Oleic acid, Palmitic acid, Tetratetracontane, alpha-Toluenesulfonyl chloride, bis(1-methylpropyl) ester Hexanedioic acid, cis-9-Tricosene, dihydro-5-(1-methylethyl)-3(2H)-Furanone, meta-Xylene, n-Docosane, n-Octacosane, n-Tetradecanoic acid, o-(phenylmethyl)-Hydroxylamine, ortho-Xylene, tetradecanal
Volatile and semivolatile organic compounds (VOCs and SVOCs)
Top health concerns for Volatile and semivolatile organic compounds (VOCs and SVOCs) (References)
| health concern or target organ | weight of evidence |
| Birth defects and developmental delays | unknown |
| Cancer | limited |
| Kidney and renal system | limited |
Other health concerns for Volatile and semivolatile organic compounds (VOCs and SVOCs) (References)
| health concern or target organ | weight of evidence |
| Skin | unknown |
| Brain and nervous system | strong |
| Reproduction and fertility | unknown |
| Sense organs | limited |
| Endocrine system | known |
| Gastrointestinal (including liver) | limited |
| Cardiovascular system | limited |
| Hematologic (blood) system | limited |
| Immune system (including sensitization and allergies) | limited |
Data gaps for Volatile and semivolatile organic compounds (VOCs and SVOCs) (References)
Data are insufficient to assess cancer potential.
Violations, restrictions, and warnings for Volatile and semivolatile organic compounds (VOCs and SVOCs) (References)
Prohibited for use in cosmetics in the European Union.
Other relevant risk considerations for Volatile and semivolatile organic compounds (VOCs and SVOCs) (References)
Not likely to be carcinogenic in humans.
Wildlife and environmental toxicity.
Toxicity Classifications (References)
| classification | governing entity/references |
| A3- Confirmed animal carcinogen with unknown relevance to humans, ACGIH (American Conference of Governmental Industrial Hygeinists) | Amer Conf of Gov't Industrial Hygienists - Carcinogens |
| Cancer hazards: recognized | P65 |
| Cardiovascular or blood toxicity hazards: suspected | EPA-HEN, RTECS |
| Chemicals in this class have been reviewed by the Cosmetics Industry Review panel. (Please see individual chemicals for details.) | Cosmetics Ingredient Review Assessments |
| Developmental toxicity hazards: suspected | ATSDR, EPA-SARA, OEHHA-CREL, ATSDR, EPA-SARA, JANK |
| Endocrine toxicity hazards: suspected | OEHHA-CREL |
| Flammable; Harmful; Harmful by inhalation and in contact with skin; Irritant; Irritating to skin | European Union - Classification & Labelling |
| Flammable; Irritant; Irritating to respiratory system | European Union - Classification & Labelling |
| Flammable; Limited evidence of reproductive toxicity (European Union classification); Possible risk of impaired fertility; Toxic; Toxic: danger of serious damage to health by prolonged exposure through inhalation; Vapours may cause drowsiness and dizziness | European Union - Classification & Labelling |
| Gastrointestinal or liver toxicity hazards: suspected | OEHHA-CREL, RTECS, EPA-HEN, RTECS |
| Group D: Not classifiable as to human carcinogenicity (EPA classification) | EPA Integrated Risk Information System (IRIS) |
| Hazardous air pollutant under Clean Air Act | EPA Hazardous Air Pollutants |
| Highly flammable; Harmful; Harmful by inhalation | European Union - Classification & Labelling |
| Highly flammable; Harmful; Harmful: may cause lung damage if swallowed; Irritant; Irritating to skin; Vapours may cause drowsiness and dizziness; Dangerous for the environment; Very toxic to aquatic organisms | European Union - Classification & Labelling |
| IARC 3: mixed or limited evidence on human cancer potential (International Agency for Research on Carcinogens) | Inter'l Agency for Research on Cancer (IARC) Carcinogens |
| IARC Group 2B: possible human carcinogen (International Agency for Research on Carcinogens) | Inter'l Agency for Research on Cancer (IARC) Carcinogens |
| Immunotoxicity hazards: suspected | IPCS |
| Inadequate data to assess carcinogenic potential (EPA classification) | EPA Integrated Risk Information System (IRIS) |
| Kidney toxicity hazards: suspected | OEHHA-CREL, RTECS, ATSDR, EPA-HEN |
| Known to be neurotoxic to humans, suspected developmental neurotoxin | Chemicals known to be neurotoxic to humans |
| Low concern for potential carcinogenicity | EPA Water Disinfection By-Products Carcinogenicity |
| Priority water pollutant under the Clean Water Act | EPA Water Quality Standards Database |
| Prohibited in EU cosmetics: must not form part of the composition of cosmetic products | European Union - Banned or Restricted in Cosmetics |
| Reproductive toxicity hazards: suspected | EPA-SARA, EPA-SARA, FRAZIER, HAZMAP |
| Respiratory toxicity hazards: suspected | EPA-HEN, RTECS, EPA-HEN, LU, OEHHA-AREL, OEHHA-CREL, RTECS |
| Skin or sense organ toxicity hazards: suspected | EPA-HEN, HAZMAP, RTECS, EPA-HEN, OEHHA-AREL, RTECS |
| Toxic, U.S. Environmental Protection Agency Toxics Release Inventory programs | EPA Toxic Release Inventory (1999) |
