chemical Class
Organophosphate Pesticide metabolites (OPs)
Chemicals in the class:
Chlorpyrifos metabolite (3,5,6-TCP), Diethylphosphate (DEP), Diethylphosphorodithidate (DEDTP), Diethylphosphorothidate (DEPT), Dimethylphosphate (DMP), Dimethylphosphorodithidate (DMDTP), Dimethylphosphorothidate (DMPT), Malathion Dicarboxylic Acid, Malathion Mono-Carboxylic Acid
Organophosphate Pesticide metabolites (OPs)
Top health concerns for Organophosphate Pesticide metabolites (OPs) (References)
| health concern or target organ | weight of evidence |
| Brain and nervous system | unknown |
Other health concerns for Organophosphate Pesticide metabolites (OPs) (References)
| health concern or target organ | weight of evidence |
| Immune system (including sensitization and allergies) | moderate |
| Cancer | limited |
| Birth defects and developmental delays | probable |
| Gastrointestinal (including liver) | limited |
| Respiratory system | limited |
| Skin | unknown |
| Reproduction and fertility | limited |
| Endocrine system | known |
Other relevant risk considerations for Organophosphate Pesticide metabolites (OPs) (References)
Wildlife and environmental toxicity.
Toxicity Classifications (References)
| classification | governing entity/references |
| Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.) - Limited | CHE Toxicant and Disease Database |
| Brain cancer (adult)* - Limited | CHE Toxicant and Disease Database |
| Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span)/Mental Retardation/Developmental Delay - Limited | CHE Toxicant and Disease Database |
| Colo-rectal cancer - Limited | CHE Toxicant and Disease Database |
| EPA: suspected endocrine disruptor | Illinois EPA Chemicals Associated with Endocrine System |
| Endocrine toxicity hazards: suspected | Keith, L.H. (ed.). Environmental Endocrine Disruptors. John Wiley & Sons, NY. 1997. http://www.wileyeurope.com/cda/product/0,,0471191450%7Cdesc%7C3037,00.html, BRUC, JNIHS, KEIT, WWF |
| Harmful; Harmful if swallowed; Dangerous for the environment; Very toxic to aquatic organisms | European Union - Classification & Labelling |
| IARC 3: mixed or limited evidence on human cancer potential (International Agency for Research on Carcinogens) | Inter'l Agency for Research on Cancer (IARC) Carcinogens |
| Immune suppression * - Good | CHE Toxicant and Disease Database |
| Known to be neurotoxic to humans, suspected developmental neurotoxin | Chemicals known to be neurotoxic to humans |
| Limited evidence in humans: nervous system toxicity; Condition: ADD/ADHD, hyperactivity; Organs/tissues affected: brain | CHE Toxicant and Disease Database |
| Low birth weight/Small for Gestational Age/Intra-Uterine Growth Retardation - Good | CHE Toxicant and Disease Database |
| Lung cancer - Limited | CHE Toxicant and Disease Database |
| Lymphoma (non-Hodgkin's) - Good | CHE Toxicant and Disease Database |
| May cause sensitization by skin contact, with allergic reaction in skin or lungs | National Library of Medicine HazMap |
| Nervous system toxicity - weight of evidence unknown/unassessed | Kamel, F. and J. A. Hoppin (2004). Association of pesticide exposure with neurologic dysfunction and disease. Environ Health Perspect 112(9): 950-8. |
| Priority substance in EU water policy | European Union - Water Framework Directive |
| Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional laibility, mood changes, euphoria). - Good | CHE Toxicant and Disease Database |
| Reproductive toxicity hazards: suspected | Frazier , L. and M. L. Hage (eds.). Reproductive Hazards of the Workplace, Wiley Europe, 1998. Table 10 (Partial List of Reproductive Toxicants) available at http://www.pharmacy.ohio-state.edu/homepage/safety/chemhygiene_table_repro.pdf. |
| Respiratory toxicity hazards: suspected | ATSDR, RTECS |
| Toxic; Toxic if swallowed; Dangerous for the environment; Very toxic to aquatic organisms | European Union - Classification & Labelling |
