chemical information
CAS RN:

7012-37-5

Chemical Class:

Polychlorinated biphenyl (PCB)

Chemical SubClass

Tri-PCB

Manufacturing/Use Status

banned for use/manufacture in the U.S.

Found in these people:

Sara Corbett, Baby #6, Baby #1, Baby #9, Baby #7, Baby #8, Baby #10, Baby #4, Baby #2, Baby #3, Baby #5, Kathy Fowler, Anonymous Adult 1, Monique Harden, Lexi Rome, Charlotte Brody, Lucy Waletsky, Andrea Martin, Bill Moyers, Michael Lerner, U.S. Representative Louise Slaughter, Sharyle Patton, Davis Baltz, Cord Blood Sample 18, Cord Blood Sample 19

Found in these locations:

NY, USA; Rockville, MD; New Orleans, LA; Mill Valley, CA; Round Hill, VA; Pleasantville, NY; Sausalito, CA; NJ, USA; Bolinas, CA; Upstate New York, NY; Berkeley, CA

Exposure routes:

Banned industrial insulators and lubricants. Residual environmental contamination results in continued exposures.


Summary

Laboratory animals. In animal studies, PCBs cause a wide variety of effects including liver and thyroid tumors; kidney, gastrointestinal, immune, urinary tract, and reproductive toxicity; altered lipid and carbohydrate metabolism; nail and nail bed changes; reduced fertility and birth defects. Specific birth defects include reproductive tract and skeletal abnormalities. PCBs are endocrine disruptors because they alter thyroid and adrenal hormone levels and function. PCBs cause significant neurotoxicity, including decreased exploratory behavior, learning, spatial and non-spatial discrimination, auditory deficits and altered levels of brain neurotransmitters (dopamine and serotonin) (ATSDR 2000b).

Humans. The effects of PCBs have been studied in humans who were exposed through diet, work, and industrial accidents. PCBs are reasonably anticipated to be human carcinogen (NTP 2002). They are associated with skin, liver, biliary tract, and intestinal cancers. Other effects of PCBs include respiratory effects, gastrointestinal damage (nausea, vomiting, abdominal pain), eye irritation, increased susceptibility to infection, and hypothyroidism (ATSDR 2000b, Persky, et al. 2001). Other possible health effects associated with PCB exposure are menstrual irregularities and decreased fertility in women. Inconsistent associations have been noted with non-Hodgkin's lymphoma, breast cancer, cardiovascular disease, sperm and fertility in males, low birth weight and head circumference (ATSDR 2000b). PCB exposure in the womb or during lactation is also associated with decreased IQ and impaired psychomotor development, decreased immune function, altered liver enzyme and lipid levels, and skin disease (chloracne) (ATSDR 2000b).


PCB-28

In polychlorinated biphenyl (PCB) family of chemicals - banned industrial insulators and lubricants; cause cancer and nervous system problems.

PCB-28 has been found in 27 of the 34 people tested in EWG/Commonweal studies. It has also been found in 35 of the 2,274 people tested in CDC biomonitoring studies.


Top health concerns for PCB-28 (References)

health concern or target organ weight of evidence
Brain and nervous systemunknown
Immune system (including sensitization and allergies)limited


Results for PCB-28

This chemical was found to co-elute with PCB-20.


in blood serum (lipid weight)

Showing results from Pollution in Minority Newborns, EWG/Commonweal Study #4, industrial chemicals and pesticides in cord blood, San Francisco Reporter, EWG Study #8, chemicals in mother and 2 children, EWG Study #3, industrial chemicals and pesticides in adults, EWG/Commonweal Study #1, industrial chemicals and pesticides in adults

EWG/Commonweal results

  • geometric mean: 0.247 ng/g (lipid weight) in blood serum
  • found in 27 of 34 people in the group

CDC biomonitoring results

  • geometric mean: 7.14 ng/g (lipid weight) in blood serum
  • found in 35 of 2274 people in the group
0 ng/g (lipid weight) in blood serum 63.8


PCB-28 results


Detailed toxicity classifications (References)

classification governing entity/references
Nervous system toxicity - weight of evidence unknown/unassessedATSDR (2000). Toxicological profile for polychlorinated biphenyls (PCBs): Health effects chapter. http://www.atsdr.cdc.gov/tfacts17.html
Limited evidence in humans - immune system toxicityATSDR (2000). Toxicological profile for polychlorinated biphenyls (PCBs): Health effects chapter. http://www.atsdr.cdc.gov/tfacts17.html