chemical information
CAS RN:

57117-44-9

Chemical Class:

Chlorinated dioxin

Chemical SubClass

Hexachlorinated dioxin

Manufacturing/Use Status

this chemical is not intentionally produced, it is a byproduct of another application

Found in these people:

Baby #3, Baby #2, Michael Lerner, Baby #5, Davis Baltz, Baby #4, Anonymous Adult 1, Monique Harden, Lexi Rome, Lucy Waletsky, Charlotte Brody, Andrea Martin, Bill Moyers, Kathy Fowler, U.S. Representative Louise Slaughter, Sharyle Patton, Cord Blood Sample 18, Cord Blood Sample 19, Cord Blood Sample 16, Cord Blood Sample 13, Cord Blood Sample 11

Found in these locations:

Bolinas, CA; Berkeley, CA; New Orleans, LA; Mill Valley, CA; Pleasantville, NY; Round Hill, VA; Sausalito, CA; NJ, USA; Rockville, MD; Upstate New York, NY


Summary

Laboratory animals. Dioxins cause toxicity to many organ systems in animals. Effects include liver and thyroid tumors; cardiovascular, skeletal, skin, immune, respiratory, neurological and reproductive toxicity; altered lipid and carbohydrate metabolism; reduced fertility and birth defects. Specific birth defects include reproductive tract and skeletal abnormalities, such as cleft palate (ATSDR 1998a). Dioxins are endocrine disruptors because they alter thyroid, reproductive, and adrenal hormone levels and function (ATSDR 1998a). Many of the lowest dose effects are developmental. For example, a one-time exposure to dioxin during fetal life can impair prostate development in male rats (Roman and Peterson 1998, Roman, et al. 1998, Timms, et al. 2002).

Humans. The effects of dioxins have been studied in humans who were exposed through diet, work, military service and industrial accidents. Dioxin (TCDD) is a known human carcinogen. It is associated with increased incidence of cancer in general and with non-Hodgkin's lymphoma and lung and soft-tissue cancer in particular (ATSDR 1998a, NTP 2002). Soft tissue includes muscle, fat, blood vessels or any of the other tissues that support, surround and protect organs of the body. Dioxin is also associated with non-cancer disorders including skin lesions (chloracne), and nervous system toxicity (ATSDR 1998a). Associations with other types of disorders are emerging. For example, recent follow-up of people exposed to an industrial explosion in Seveso, Italy (the highest known population exposure to TCDD) suggest that dioxin may also be associated with breast cancer (Warner, et al. 2002), menstrual irregularities (Eskenazi, et al. 2002), altered thyroid function, and diabetes (Kogevinas 2001). Risk of developing diabetes or glucose intolerance is also increased in military personnel who were exposed to dioxin-contaminated herbicide (Agent Orange) in the Vietnam War (Longnecker, et al. 2001). Although developmental effects of dioxin have not been adequately studied in humans, several studies have linked dioxin to altered sex ratio (in favor of females) (Mocarelli, et al. 2000).


1,2,3,7,8,9-HxCDD (hexadioxin)

In dioxin family of chemicals - pollutants from PVC production, industrial bleaching, incineration; cause cancer, may harm hormone system.

1,2,3,7,8,9-HxCDD (hexadioxin) has been found in 23 of the 34 people tested in EWG/Commonweal studies. It has also been found in 758 of the 4,821 people tested in CDC biomonitoring studies.


Top health concerns for 1,2,3,7,8,9-HxCDD (hexadioxin) (References)

health concern or target organ weight of evidence
Immune system (including sensitization and allergies)limited
Birth defects and developmental delaysunknown


Results for 1,2,3,7,8,9-HxCDD (hexadioxin)

in blood serum (lipid weight)

Showing results from EWG/Commonweal Study #4, industrial chemicals and pesticides in cord blood, Pollution in Minority Newborns, EWG/Commonweal Study #1, industrial chemicals and pesticides in adults, San Francisco Reporter, EWG Study #3, industrial chemicals and pesticides in adults

EWG/Commonweal results

  • geometric mean: 3.17 pg/g (lipid weight) in blood serum
  • found in 23 of 34 people in the group

CDC biomonitoring results

  • geometric mean: 2.98 pg/g (lipid weight) in blood serum
  • found in 758 of 4821 people in the group
0 pg/g (lipid weight) in blood serum 260


1,2,3,7,8,9-HxCDD (hexadioxin) results


Detailed toxicity classifications (References)

classification governing entity/references
Limited evidence in humans - immune system toxicityATSDR (1998). Toxicological profile for chlorinated dibenzo-o-dioxins (CDDs): Health effects chapter. http://www.atsdr.cdc.gov/toxprofiles/tp104.html
Birth defects - weight of evidence unknown/unassessedATSDR (1998). Toxicological profile for chlorinated dibenzo-o-dioxins (CDDs): Health effects chapter. http://www.atsdr.cdc.gov/toxprofiles/tp104.html