banned for use/manufacture in the U.S.
Found in these people:
Found in these locations:
Mill Valley, CA; Rockville, MD; Upstate New York, NY; NY, USA
In laboratory animals, mirex causes liver toxicity (impaired biliary function, increase liver weight, cellular effects, increased lipid accumulation, decreased liver glycogen, altered liver enzymes); increased cholesterol and triglycerides; hematological effects (hypoglycemia); neurotoxicity (hyperexcitability, tremors, convulsions, lethargy); increased adrenal weight; increased corticosterone; decreased spleen weight; thyroid toxicity (cellular changes, decreased thyroid hormones); reproductive toxicity (decreased ovarian and uterine weight, decreased fertility). Developmental toxicity includes fetal death, decreased birth weight; undescended testicles; changes in brain structure; delayed bone development; cataracts; irregular heart beat and cardiac malformations (ATSDR 1995b).
Very little is known about mirex toxicity in humans (ATSDR 1995b).
Organochlorine chemical, a class largely banned in the U.S. that builds up in the body over time, linked to cancer and reproductive harm.
Mirex has been found in 19 of the 27 people tested in EWG/Commonweal studies. It has also been found in 700 of the 4,821 people tested in CDC biomonitoring studies.
Top health concerns for Mirex (References)
|health concern or target organ||weight of evidence|
|Reproduction and fertility||unknown|
Results for Mirex
in blood serum (lipid weight)
- geometric mean: 0.228 ng/g (lipid weight) in blood serum
- found in 19 of 27 people in the group
- geometric mean: 4.16 ng/g (lipid weight) in blood serum
- found in 700 of 4821 people in the group
|0||ng/g (lipid weight) in blood serum||2960|
Detailed toxicity classifications (References)
|Reproductive effects - weight of evidence unknown/unassessed||Damgaard, I. N., N. E. Skakkebaek, et al. (2006). Persistent pesticides in human breast milk and cryptorchidism. Environ Health Perspect 114(7): 1133-8.|