use/production has been voluntarily discontinued in the U.S.
Found in these people:
Found in these locations:
San Francisco, CA; La Habra Heights, CA; Evergreen, CO; Dorchester, MA; Jamiaca Plain, MA; Ann Arbor, MI; Raytown, MO; Missoula, MT; Austin, TX; Belvedere, CA; VA, USA
Fire retardant in foam furniture, carpet padding, computers, televisions. Pollutant in house dust, food.
PBDEs are brominated fire retardants, intentionally added to flexible foam furniture--primarily mattresses, couches, padded chairs, pillows, carpet padding and vehicle upholstry.
These chemicals were withdrawn from the US market in 2005 due to their toxicity to laboratory animals, and their detection as contaminants in humans, wildlife, house and office buildings and common foods. (Sjodin 2003) People are primarily exposed to PBDEs in their homes, offices and vehicles. Secondary sources are foods, primarily meat, dairy, fish and eggs. (Schecter, Papke et al. 2005)
Studies of laboratory animals link PBDE exposure to an array of adverse health effects including thyroid hormone disruption, permanent learning and memory impairment, behavioral changes, hearing deficits, delayed puberty onset, decreased sperm count, and fetal malformations. (Darnerud 2003; Hale R.C. 2003) Research in animals shows that exposure to brominated fire retardants in-utero or during infancy leads to more significant harm than exposure during adulthood, and at much lower levels.(Viberg H 2006)
PBDEs are bioaccumulative and lipophilic ('fat-loving') therefore highly persistent in people and the environment. The chemicals build up in the body, are stored in fatty tissues and body fluids, such as blood and breast milk, and can be passed on to fetuses and infants during pregnancy and lactation. Despite their phase-out from commerce, human exposure will continue for decades to come.
Brominated fire retardants used in polyurethan foam and plastics. These PBDEs are neurotoxic and persist in people and the environment. They were withdrawn from the market in the U.S. in 2005.
PBDE-126 has been found in 13 of the 98 people tested in EWG/Commonweal studies.
Top health concerns for PBDE-126 (References)
|health concern or target organ||weight of evidence|
|Reproduction and fertility||unknown|
|Brain and nervous system||unknown|
Results for PBDE-126
in blood serum (lipid weight)
- geometric mean: 0.00203 ng/g (lipid weight) in blood serum
- found in 3 of 78 people in the group
|0||ng/g (lipid weight) in blood serum||0.137|
in breast milk (lipid weight)
- geometric mean: 0.0067 ppb (lipid weight) in breast milk
- found in 10 of 20 people in the group
|0||ppb (lipid weight) in breast milk||0.22|
Detailed toxicity classifications (References)
|Reproductive effects - weight of evidence unknown/unassessed||McDonald, T. A. (2002). A perspective on the potential health risks of PBDEs. Chemosphere 46: 11.|
|Nervous system toxicity - weight of evidence unknown/unassessed||Viberg, H., Fredriksson, A., Jakobsson, E., Orn, U., Eriksson, P. (2003). Neurobehavioral derangements in adult mice receiving decabrominated diphenyl ether (PBDE 209) during a defined period of neonatal brain development. Toxicol Sci 76(1): 112-20.|