EWG's Guide to Healthy Cleaning | HEXYL SALICYLATE

EWG's Guide to
Healthy Cleaning

Discover EWG VERIFIED^®

GET UPDATES DONATE

HAZARD SCORE RANGE

HOW WE DETERMINE SCORES LEARN MORE ABOUT EWG VERIFIED®

HOME / INGREDIENTS / Hexyl salicylate

HEXYL SALICYLATE

SEARCH PRODUCTS

Find Products With This Ingredient

COMMONLY FOUND IN

air freshener cleaner, all-purpose/multi-surface cleaner, bathroom, general cleaner, tub/tile/sink cleaner, toilet bowl dish detergent or soap, hand cleaner, kitchen, general laundry additive laundry detergent laundry detergent, he/high efficiency laundry, fabric softener cleaner, disinfectant laundry detergent pods, powder products for babies laundry detergent, cold water

SYNONYMS

ANW-44503, ACMC-209V1L, SALICYLIC ACID-HEXYL ESTER, EC 228-408-6, CHEMBL495972, DTXSID4038924, CTK3J0025, ZINC2034026, 9447AB, SCHEMBL113059

RESTRICTED

EWG VERIFIED products cannot contain this ingredient without adequate substantiation.

Common Concerns

See how this product scores for common concerns.

No Data

Asthma / Respiratory
LOW

Skin Allergies & Irritation
SOME

Developmental & Reproductive Toxicity
No Data

Cancer
No Data

Environment

Top Scoring Factors

Evidence of developmental/endocrine/reproductive effects; damage to vision; skin irritation/allergies/damage

Ingredient concerns

CONCERNS

Health Issue	Level of Concern	Source

May cause an allergic skin reaction Only in: Household Cleaners	some	European Chemicals Agency (ECHA): GHS Data from ECHA Website
NTP Toxcast scored 1.5-2.5	some	National Toxicology Program (NTP): EWG Toxcast Analysis
Causes skin irritation Only in: Household Cleaners	some	European Chemicals Agency (ECHA): GHS Data from ECHA Website
causes serious eye irritation Only in: Household Cleaners	some	European Chemicals Agency (ECHA): GHS Data from ECHA Website
The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.	some	Cosmetic Ingredient Review (CIR): CIR Assessments
The Cosmetic Ingredient Review panel concludes this substance is safe for use when formulated to be non-irritating.	some	Cosmetic Ingredient Review (CIR): CIR Assessments
Hexyl salicylate caused skin irritation in animals.	some	Nada Oršolić, Jadranka Skurić, Domagoj Dikić & Gabrijela Stanić. 2014. Inhibitory effect of a propolis on di-n-propyl disulfide or n-hexyl salycilate-induced skin irritation, oxidative stress and inflammatory responses in mice. Fitoterapia 93, 18-30.
Skin sensitization observed in animal testing.	some	A. Lapczynski, L. Jones, D. McGinty, S. Bhatia, C. S. Letizia & A. M. Api. 2007. Fragrance material review on hexyl salicylate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 45 Suppl 1, S410-7.
Equivocal evidence of minor skin irritation in human and animal studies.	low	A. Lapczynski, L. Jones, D. McGinty, S. Bhatia, C. S. Letizia & A. M. Api. 2007. Fragrance material review on hexyl salicylate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 45 Suppl 1, S410-7.
No evidence of skin sensitization in limited human testing.	low	Niels H. Bennike, Claus Zachariae & Jeanne D. Johansen. 2019. Optimal patch test concentration for three widely used sensitizing fragrance substances without mandatory labelling in cosmetics. Contact dermatitis 80(5), 325-327.
The European Commission's Scientific Committee on Consumer Safety reports this substance shows negative results for causing contact allergy in humans.	low	EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)