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D

FD&C RED 40

 
This substance ranges from C to D depending on concentration/usage.
Asthma/Respiratory
 
No Data, Some Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
No Data, Some Concern
 
Cancer
 
Some Concern
 
Environment
 
Some Concern
 
Top scoring factors: Evidence of general systemic/organ effects; damage to DNA; cancer
FD&C RED 40 can be found in 1 product.
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Evidence

Health issue
 
Level of Concern
 
Source
Review article concluded that chemical can cause hyperactivity in children
Only in: Food
 
some
 
Sarah Kobylewski & Michael F. Jacobson. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
Review article concluded that chemical causes cancer
Only in: Food
 
some
 
Sarah Kobylewski & Michael F. Jacobson. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
EFSA finds that there is "limited evidence" that Allura Red in a mixture with other synthetic colors and sodium benzoate has a "small and statistically significant effect on activity and attention in children selected from the general population."
Only in: Food
 
some
 
European Food Safety Authority. 2009. Scientific Opinion on the re-evaluation of Allura Red AC (E 129) as a food additive. EFSA Journal 7(11), 1327.
A review article concluded that chemical possibly caused brain and bladder tumors in rats.
Only in: Food
 
some
 
Sarah Kobylewski & Michael F. Jacobson. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
A review study found that cell-based screening tests suggest the potential for neurotoxicity.
Only in: Food
 
some
 
Sarah Kobylewski & Michael F. Jacobson. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
EFSA concludes that some sensitive individuals may experience allergic reactions at dose levels within the ADI.
Only in: Food
 
some
 
European Food Safety Authority. 2009. Scientific Opinion on the re-evaluation of Allura Red AC (E 129) as a food additive. EFSA Journal 7(11), 1327.
Review article concluded that chemical caused hypersensitivity reactions.
Only in: Food
 
some
 
Sarah Kobylewski & Michael F. Jacobson. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
A review article concluded that 15% of people suffering from skin allergy reacted to Red 40 in a skin allergy test.
Only in: Food
 
some
 
Sarah Kobylewski & Michael F. Jacobson. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.

Impurities

Health issue
 
Level of Concern
 
Source
Impurity: ANILINE
Suspected of causing genetic defects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 1-NAPHTHYLAMINE
Known to cause cancer
 
some
 
Prop 65 - CA Proposition 65
Impurity: 6-METHOXY-M-TOLUIDINE
May cause cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Known to cause cancer
 
some
 
Prop 65 - CA Proposition 65
Impurity: 6-METHOXY-M-TOLUIDINE
Known to cause cancer
 
some
 
Prop 65 - CA Proposition 65
Impurity: ANILINE
Very toxic to aquatic life
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Suspected of causing cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Causes damage to organs through prolonged or repeated exposure
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 6-METHOXY-M-TOLUIDINE
Reasonably Anticipated To Be Human Carcinogen
 
some
 
NTP 12th RoC - NTP RoC
Impurity: ANILINE
Probably carcinogenic to humans
 
some
 
EPA Integrated Risk Information System (IRIS) - Cancer - Environmental Protection Agency (EPA)
Impurity: ANILINE
Toxic if swallowed
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Toxic if inhaled
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Toxic in contact with skin
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 1-NAPHTHYLAMINE
Toxic to aquatic life with long lasting effects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 1-NAPHTHYLAMINE
Harmful if swallowed
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 6-METHOXY-M-TOLUIDINE
Possibly carcinogenic to humans
 
some
 
IARC 103 - IARC
Impurity: 6-METHOXY-M-TOLUIDINE
Harmful if swallowed
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
confirmed animal carcinogen with unknown relevance to humans
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: ANILINE
May cause an allergic skin reaction
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ANILINE
Causes serious eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 1-NAPHTHYLAMINE
Not classifiable as to its carcinogenicity to humans
 
low
 
IARC 103 - IARC
Impurity: ANILINE
Not classifiable as to its carcinogenicity to humans
 
low
 
IARC 103 - IARC
Impurity: ANILINE
EPA testing shows this substance has moderate acute toxicity to aquatic life
 
low
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
Impurity: ANILINE
EPA testing shows this substance has low acute toxicity to aquatic life
 
low
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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