developmentb
Substance Image
See more:

Want email updates about EWG's Guide to Healthy Cleaning, exclusive tips, action alerts, promotions to support our work and more from EWG?

Sign up today!
*You can opt-out at any time.
C

BHT

 
Asthma/Respiratory
 
Some Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
High Concern
 
Cancer
 
High Concern
 
Environment
 
No Data, Some Concern
 
Top scoring factors: Evidence of developmental/endocrine/reproductive effects; cancer; blood-related effects
BHT can be found in 12 products.
Print
 
Share on:

Evidence

Health issue
 
Level of Concern
 
Source
The European Food Safety Authority reports that this substance can cause reproductive and developmental toxicity in animals.
Only in: Food
 
high
 
European Food Safety Authority. 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
The European Food Safety Authority reports that this substance can cause birth weight effects in animals.
Only in: Food
 
high
 
European Food Safety Authority. 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
The European Food Safety Authority reports that this substance can cause hemorrhagic effects in animals at high doses.
Only in: Food
 
high
 
European Food Safety Authority. 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
The European Food Safety Authority reports that this substance can cause thyroid effects in animals.
Only in: Food
 
high
 
European Food Safety Authority. 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
The European Food Safety Authority reports that this substance can cause liver tumors in animals.
Only in: Food
 
high
 
European Food Safety Authority. 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
The European Food Safety Authority reports that this substance can cause lung cancer in animals.
Only in: Food
 
moderate
 
European Food Safety Authority. 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
The European Food Safety Authority reports that this substance can cause hyperplasia in animals.
Only in: Food
 
moderate
 
European Food Safety Authority. 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
The European Food Safety Authority reports that this substance can cause allergies in people.
Only in: Food
 
some
 
European Food Safety Authority. 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
A peer-reviewed study found this substance caused adverse developmental effects in rats.
 
some
 
C. V. Vorhees, R. E. Butcher, R. L. Brunner & T. J. Sobotka. 1981. Developmental neurobehavioural toxicity of butylated hydroxytoluene in rats. Food and cosmetics toxicology 19(2), 153-62.
upper respiratory tract irritation
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
NTP Toxcast scored 3.5-4.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
Causes skin irritation
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Not classifiable as to its carcinogenicity to humans
 
low
 
IARC 103 - IARC
not classifiable as a human carcinogen
 
low
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
The European Food Safety Authority reports that this substance is not associated with stomach cancer in people.
Only in: Food
 
low
 
European Food Safety Authority. 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
Legal Disclaimer | Methodology | FAQs