developmentb
Substance Image
See more:

Want email updates about EWG's Guide to Healthy Cleaning, exclusive tips, action alerts, promotions to support our work and more from EWG?

Sign up today!
*You can opt-out at any time.
D

METHYLISOTHIAZOLINONE

 
This substance ranges from C to D depending on concentration/usage.
Asthma/Respiratory
 
No Data, Some Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
No Data, Some Concern
 
Cancer
 
No Data, Some Concern
 
Environment
 
Moderate Concern
 
Top scoring factors: Evidence of acute aquatic toxicity; skin irritation/allergies/damage
METHYLISOTHIAZOLINONE can be found in 358 products.
Print
 
Share on:

Evidence

Health issue
 
Level of Concern
 
Source
The US EPA reports the LC50 value is very toxic to aquatic life.
 
high
 
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
 
some
 
Detergents Ingredients Database - EU Ecolabel
The US EPA reports this substance is a skin sensitizer.
 
some
 
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
The US EPA reports this substance causes skin irritation.
 
some
 
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
NIOSH reports that this substance is a skin sensitizer.
 
some
 
Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
A review article reports that this substance causes contact allergies.
 
some
 
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
NIOSH reports that this substance is a skin irritant.
 
some
 
Calvin K. Cook & Deborah Friedman. 1996. Health Hazard Evaluation Report, HEA 94–0402–2573.
A review article reports that this substance is a skin sensitizer.
 
some
 
M D Lundov, T Krongaard, T L Menné & J D ohansen. 2011. Methylisothiazolinone contact allergy: a review. The British journal of dermatology 165(6), 1178-82.
A peer-reviewed study reports that this substance is a skin sensitizer.
 
some
 
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
A peer-reviewed study reports that this substance causes allergic contact dermatitis.
 
some
 
Paula Maio, Rodrigo Carvalho, Cristina Amaro, Raquel Santos & Jorge Cardoso. 2012. Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a Contact Dermatitis Unit. Cutaneous and ocular toxicology 31(2), 151-3.
A peer-reviewed study reports this substance causes dermatitis.
 
some
 
Robert Willi, Florian Pfab, Thomas Zilker, Jeroen Buters, Peter Schalock, Johannes Huss-Marp, Antonia Todorova, Johannes Ring & Ulf Darsow. 2011. Danger from the workplace: allergic contact dermatitis from the first exposure to isothiazolinones. Contact dermatitis 64(6), 361-2.
A peer-reviewed study reports that this substance is a skin sensitizer.
 
some
 
D. A. Basketter, R. Rodford, I. Kimber, I. Smith & J. E. Wahlberg. 1999. Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. Contact dermatitis 40(3), 150-4.
The US EPA reports it is unknown if this substance is carcinogenic.
 
low
 
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
The European Union Ecolabel program reports this substance in inherently biodegradable.
 
low
 
Detergents Ingredients Database - EU Ecolabel
The US EPA reports this substance is unlikely to accumulate in fish at a significant level.
 
low
 
U.S. Environmental Protection Agency (EPA). 1998. Reregistration Eligibility Decision (RED) Methylisothiazolinone. EPA738-R-98-012.
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
Legal Disclaimer | Methodology | FAQs