Health issue
Level of Concern
Source
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.
some
EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)
NTP Toxcast scored 2.5-3.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
Peppermint oil was genotoxic in in vitro tests.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
May cause an allergic skin reaction
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Brain lesions were observed in rats repeatedly dosed with peppermint oil.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
The Cosmetic Ingredient Review Panel concluded this substance is safe for use when formulated to be non-sensitizing.
some
Cosmetic Ingredient Review (CIR): CIR Assessments
This substance is predicted to be genotoxic
some
Environmental Protection Agency (EPA): CompTox Chemicals Dashboard
Peppermint oil exhibited low acute oral toxicity in animal tests
low
Cosmetic Ingredient Review (CIR): CIR Assessments
Peppermint oil exhibited antioxidant properties in vitro.
low
Zhaohai Wu, Bie Tan, Yanhong Liu, James Dunn, Patricia Martorell Guerola, Marta Tortajada, Zhijun Cao & Peng Ji. 2019. Chemical Composition and Antioxidant Properties of Essential Oils from Peppermint, Native Spearmint and Scotch Spearmint. Molecules (Basel, Switzerland) 24(15).
A review article reports this substance may have anticarcinogenic activity
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.
A peer-reviewed study reports that botanical oils prevent oxidative damage.
low
Kevin P. Anthony, Suziat A. Deolu-Sobogun & Mahmoud A. Saleh. 2012. Comprehensive assessment of antioxidant activity of essential oils. Journal of food science 77(8), C839-43.
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
low
U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)
A review article reports this substance is not mutagenic
low
F. Bakkali, S. Averbeck, D. Averbeck & M. Idaomar. 2008. Biological effects of essential oils--a review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 46(2), 446-75.