Health issue
Level of Concern
Source
Synthetic food dyes are associated with adverse neurobehavioral outcomes in children.
Only in: Food Scores®
high
2021. Potential Neurobehavioral Effects of Synthetic Food Dyes in Children. California Environmental Protection Agency. Office of Environmental Health Hazard Assessment.
Structurally related substances are classified by IARC as known, probable, and possible human carcinogens (International Agency for Research on Carcinogens).
moderate
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
A review study found that cell-based screening tests suggest the potential for neurotoxicity.
some
Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
A review study found that cell-based screening tests suggest the potential for neurotoxicity.
some
Peer Reviewed Literature: Kobylewski, S. & Jacobson, M.F. 2012. Toxicology of food dyes. International journal of occupational and environmental health 18(3), 220-46.
NTP Toxcast scored 2.5-3.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
The European Commission's Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers reports this substance can irritate the skin.
some
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
NTP Toxcast scored 2.5-3.5
some
National Toxicology Program (NTP): EWG Toxcast Analysis
The European Commission's Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers reports this substance can irritate the skin.
some
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Neurobehavioral effects observed in animal study.
some
Toyohito Tanaka, Osamu Takahashi, Akiko Inomata, Akio Ogata & Dai Nakae. 2012. Reproductive and neurobehavioral effects of brilliant blue FCF in mice. Birth defects research. Part B, Developmental and reproductive toxicology 95(6), 395-409.
Not classifiable as to its carcinogenicity to humans
low
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Not classifiable as to its carcinogenicity to humans
low
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
acute toxicity, oral LD50 (mg/kg)
low
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
acute toxicity, oral LD50 (mg/kg)
low
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
No evidence of reproductive or developmental toxicity in animal testing.
low
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Little evidence of genotoxicity in animal or in vitro testing.
low
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Not found to be carcinogenic in animal testing.
low
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
EFSA panel concluded there is no concern for genotoxicity.
low
European Food Safety Authority. 2010. Scientific Opinion on the re-evaluation of Brilliant Blue FCF (E 133) as a food additive. EFSA Journal 8(11), 1853.
No evidence of reproductive or developmental toxicity in animal testing.
low
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Little evidence of genotoxicity in animal or in vitro testing.
low
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
Not found to be carcinogenic in animal testing.
low
The Scientific Committee on Cosmetic Products and Non-Food Products Intended for Consumers. 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING ACID BLUE 9.
EFSA panel concluded there is no concern for genotoxicity.
low
European Food Safety Authority. 2010. Scientific Opinion on the re-evaluation of Brilliant Blue FCF (E 133) as a food additive. EFSA Journal 8(11), 1853.
Health issue
Level of Concern
Source
Impurity: ANILINE
Suspected of causing genetic defects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Suspected of causing cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Causes damage to organs through prolonged or repeated exposure
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Very toxic to aquatic life
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Known to cause cancer
some
California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)
Impurity: CADMIUM
Suspected of causing genetic defects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
May cause cancer
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Causes damage to organs through prolonged or repeated exposure
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Very toxic to aquatic life
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Very toxic to aquatic life with long lasting effects
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Fatal if inhaled
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Suspected of damaging fertility.
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Suspected of damaging the unborn child.
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
Carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: CADMIUM
Known To Be Human Carcinogen
some
National Toxicology Program (NTP): NTP 14th Report on Carcinogens
Impurity: ANILINE
Probably carcinogenic to humans
some
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
Impurity: ANILINE
Probably carcinogenic to humans
some
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: CADMIUM
Probably carcinogenic to humans
some
Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer
Impurity: ANILINE
Toxic if swallowed
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Toxic in contact with skin
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Toxic if inhaled
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: CADMIUM
kidney damage
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: CADMIUM
suspected human carcinogen
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ANILINE
suspected of causing genetics defects
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
causes damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
confirmed animal carcinogen with unknown relevance to humans
some
American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis
Impurity: ANILINE
May cause an allergic skin reaction
Only in: Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
Toxic in contact with skin
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
toxic if inhaled
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Toxic of swallowed
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Causes serious eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Household Cleaners
some
EU GHS Hazard Labeling Codes: GHS Hazard Codes
Impurity: ANILINE
may cause damage to organs through prolonged or repeated exposure
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
May cause an allergic skin reaction
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
may cause respiratory irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Causes skin irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Causes serious eye damage
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
causes serious eye irritation
Only in: Household Cleaners
some
European Chemicals Agency (ECHA): GHS Data from ECHA Website
Impurity: ANILINE
Not classifiable as to its carcinogenicity to humans
low
International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)
Impurity: ANILINE
EPA testing shows this substance has moderate acute toxicity to aquatic life
low
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database
Impurity: ANILINE
EPA testing shows this substance has low acute toxicity to aquatic life
low
Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database