EWG's Guide to Healthy Cleaning | CI 45350 (D&C Yellow No. 7 or 8)

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CI 45350 (D&C Yellow No. 7 or 8)

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COMMONLY FOUND IN

cleaner, degreaser, heavy duty cleaner, professional

SYNONYMS

C.I. 45350.1, D01261, EC 219-031-8, 12291-EP2270011A1, 3',6'-DIHYDROXY-3H-SPIRO[ISOBENZO[B]FURAN-1,9'-XANTHEN]-3-ONE, FLUORESCEIN, UNITED STATES PHARMACOPEIA (USP) REFERENCE STANDARD, 12,15-DIHYDROXYSPIRO[3-HYDROISOBENZOFURAN-3,9'-XANTHENE]-1-ONE, FLUORESCEIN, EUROPEAN PHARMACOPOEIA (EP) REFERENCE STANDARD, E89FA0B4-4844-46A2-AF9B-29ECA50E5599, FLUORESCEIN LOW RANGE DNA STANDARD, FLUORESCEIN-LABELED MARKER FOR DNA ELECTROPHORESIS

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EWG VERIFIED products cannot contain this ingredient without adequate substantiation.

Common Concerns

See how this product scores for common concerns.

No Data

Asthma / Respiratory
No Data

Skin Allergies & Irritation
SOME

Developmental & Reproductive Toxicity
No Data

Cancer
No Data

Environment

Top Scoring Factors

No information available on this substance.

Ingredient concerns

CONCERNS

Health Issue	Level of Concern	Source

A review article concludes this substance may be a develomental toxin based on evidence in humans and animals.	some	Raphael Alford, Haley M. Simpson, Josh Duberman, G. Craig Hill, Mikako Ogawa, Celeste Regino, Hisataka Kobayashi & Peter L. Choyke. 2009. Toxicity of organic fluorophores used in molecular imaging: literature review. Molecular imaging 8(6), 341-54.
NTP Toxcast scored 2.5-3.5	some	National Toxicology Program (NTP): EWG Toxcast Analysis
NTP Toxcast scored 2.5-3.5	some	National Toxicology Program (NTP): EWG Toxcast Analysis
A study by the National Toxicology Program reports this substance was genotoxic in vitro.	some	B. C. Myhr & W. J. Caspary. 1991. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program. Environmental and molecular mutagenesis 18(1), 51-83.
A review article reports that adverse reactions to this substance have been reported in humans.	some	Ilyse S. Kornblau & Jaafar F. El-Annan. 1900. Adverse reactions to fluorescein angiography: A comprehensive review of the literature. Survey of ophthalmology 64(5), 679-693.
causes serious eye irritation Only in: Household Cleaners	some	European Chemicals Agency (ECHA): GHS Data from ECHA Website
causes serious eye irritation Only in: Household Cleaners	some	European Chemicals Agency (ECHA): GHS Data from ECHA Website
A peer-reviewed article reports that people with a history of drug allergy may have adverse reactions to this substance.	some	Zhaoan Su, Panpan Ye, Yan Teng, Lixia Zhang & Xiaohong Shu. 2012. Adverse reaction in patients with drug allergy history after simultaneous intravenous fundus fluorescein angiography and indocyanine green angiography. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 28(4), 410-3.
A peer-reviewed article reports that allergic reactions to this substance are observed in humans.	some	Dimitrios C. Kalogeromitros, Michael P. Makris, Xenophon S. Aggelides, Anagnostis I. Mellios, Fani C. Giannoula, Kyriaki A. Sideri, Alexander A. Rouvas & Panagiotis G. Theodossiadis. 2011. Allergy skin testing in predicting adverse reactions to fluorescein: a prospective clinical study. Acta ophthalmologica 89(5), 480-3.
Low acute oral toxicty.	low	Raphael Alford, Haley M. Simpson, Josh Duberman, G. Craig Hill, Mikako Ogawa, Celeste Regino, Hisataka Kobayashi & Peter L. Choyke. 2009. Toxicity of organic fluorophores used in molecular imaging: literature review. Molecular imaging 8(6), 341-54.