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F

2-BUTOXYETHANOL

 
This substance ranges from C to F depending on concentration/usage.
Asthma/Respiratory
 
Some Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
Some Concern
 
Cancer
 
Some Concern
 
Environment
 
Low Concern
 
Top scoring factors: Evidence of digestive system effects; blood-related effects; general systemic/organ effects
2-BUTOXYETHANOL can be found in 14 products.
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Evidence

Health issue
 
Level of Concern
 
Source
A U.S. Environmental Protection Agency review finds inhalation of 2-butoxyethanol causes liver damage in lab animals.
 
high
 
U.S. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F.
A U.S. Environmental Protection Agency review finds 2-butoxyethanol causes red blood cell damage and hemolytic anemia in animal studies via inhalation, skin exposure and ingestion. Humans may be less sensitive.
 
high
 
U.S. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F.
A U.S. Environmental Protection Agency review finds inhalation of 2-butoxyethanol causes forestomach ulcers in lab animals.
 
high
 
U.S. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F.
A U.S. Environmental Protection Agency review finds ingestion of 2-butoxyethanol causes liver damage in lab animals.
 
high
 
U.S. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F.
Harmful if swallowed
Only in: Household Cleaners
 
moderate
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Harmful if inhaled
Only in: Household Cleaners
 
moderate
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
A U.S. Environmental Protection Agency review finds inhalation of 2-butoxyethanol causes hyperplasia of the stomach lining and bone marrow in lab animals.
 
moderate
 
U.S. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F.
Harmful in contact with skin
Only in: Household Cleaners
 
moderate
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Causes central nervous system depression
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
confirmed animal carcinogen with unknown relevance to humans
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
A U.S. Environmental Protection Agency review finds inhalation of low levels of 2-butoxyethanol causes respiratory irritation in humans.
 
some
 
U.S. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F.
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
upper respiratory tract irritation
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Causes respiratory irritation
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Causes skin irritation
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Causes serious eye irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
NTP Toxcast scored 0.5-1.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
Not classifiable as to its carcinogenicity to humans
 
low
 
IARC 103 - IARC
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
Only in: Household Cleaners
 
low
 
Detergents Ingredients Database - EU Ecolabel
The European Union Ecolabel program reports this substance is readily biodegradable.
 
low
 
Detergents Ingredients Database - EU Ecolabel
A U.S. Environmental Protection Agency review suggests 2-butoxyethanol is not mutagenic.
 
low
 
U.S. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F.
A U.S. Environmental Protection Agency review finds 2-butoxyethanol is not toxic to reproduction or development.
 
low
 
U.S. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F.

Impurities

Health issue
 
Level of Concern
 
Source
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity
 
some
 
Prop 65 - CA Proposition 65
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to females)
 
some
 
Prop 65 - CA Proposition 65
Impurity: ETHYLENE OXIDE
Known to cause reproductive toxicity (to males)
 
some
 
Prop 65 - CA Proposition 65
Impurity: ETHYLENE OXIDE
Carcinogenic to humans
 
some
 
IARC 103 - IARC
Impurity: ETHYLENE OXIDE
Known To Be Human Carcinogen
 
some
 
NTP 12th RoC - National Toxicology Program (NTP)
Impurity: ETHYLENE OXIDE
May cause cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ETHYLENE OXIDE
May cause genetic defects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 1,4-DIOXANE
Suspected of causing cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 1,4-DIOXANE
Known to cause cancer
 
some
 
Prop 65 - CA Proposition 65
Impurity: ETHYLENE OXIDE
Known to cause cancer
 
some
 
Prop 65 - CA Proposition 65
Impurity: 1,4-DIOXANE
Reasonably Anticipated To Be Human Carcinogen
 
some
 
NTP 12th RoC - National Toxicology Program (NTP)
Impurity: ETHYLENE OXIDE
Toxic if inhaled
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ETHYLENE OXIDE
Causes peritoneal cancer
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: ETHYLENE OXIDE
Causes leukemia
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: 1,4-DIOXANE
liver damage
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: 1,4-DIOXANE
Causes cancer
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: ETHYLENE OXIDE
Causes skin corrosion
Only in: Oven Cleaner; Drain Opener/Clog Remover
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: ETHYLENE OXIDE
central nervous system impairment
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: ETHYLENE OXIDE
Causes reproductive effects
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: ETHYLENE OXIDE
cancer
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: ETHYLENE OXIDE
Asthmagen (irritation)
 
some
 
AOEC Asthmagen list - AOEC
Impurity: ETHYLENE OXIDE
Causes pulmonary edema
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: ETHYLENE OXIDE
suspected human carcinogen
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: 1,4-DIOXANE
Possibly carcinogenic to humans
 
some
 
IARC 103 - IARC
Impurity: ETHYLENE OXIDE
Asthmagen
 
some
 
AOEC Asthmagen list - AOEC
Impurity: 1,4-DIOXANE
confirmed animal carcinogen with unknown relevance to humans
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: ETHYLENE OXIDE
May cause respiratory irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 1,4-DIOXANE
May cause respiratory irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 1,4-DIOXANE
Causes respiratory irritation
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: ETHYLENE OXIDE
Causes respiratory irritation
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: ETHYLENE OXIDE
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: 1,4-DIOXANE
Causes skin irritation
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: ETHYLENE OXIDE
Causes skin irritation
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: ETHYLENE OXIDE
Causes eye corrosion
Only in: Drain Opener/Clog Remover; Oven Cleaner
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: 1,4-DIOXANE
Causes serious eye irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ETHYLENE OXIDE
Causes serious eye irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: ETHYLENE OXIDE
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
Impurity: 1,4-DIOXANE
EPA testing shows this substance has low acute toxicity to aquatic life
 
low
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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