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HOME / INGREDIENTS / D-limonene


C

d-Limonene

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COMMONLY FOUND IN


SYNONYMS

(R)-(+)-LIMONENE, 95%, (R)-(+)-LIMONENE, 97%, ZINC967513, CHEMBL449062, DSSTOX_GSID_20778, (+)-LIMONENE, STABILIZED WITH 0.03% TOCOPHEROL, DSSTOX_RID_75785, EC 227-813-5, (4R)-LIMONENE DERIVATIVES, PARA-MENTHA-1,8-DIENE


RESTRICTED

EWG VERIFIED products cannot contain this ingredient without adequate substantiation.

Common Concerns

See how this product scores for common concerns.

  • SOME
    Asthma / Respiratory
  • SOME
    Skin Allergies & Irritation
  • LOW
    Developmental & Reproductive Toxicity
  • LOW
    Cancer
  • No Data
    Environment


Top Scoring Factors

Evidence of acute aquatic toxicity; skin irritation/allergies/damage; respiratory effects


Ingredient concerns

  • CONCERNS
Health Issue Level of Concern Source
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EPA testing shows this substance has high acute toxicity to aquatic life

some

Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database

Recognized by the European Union as a skin allergen

some

EU Cosmetics Directive: Allergen list

The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.

some

EU Cosmetics Directive: Opinion on Frangrance allergens in cosmetics (2011)

dermatitis, skin allergy

some

U.S. Environmental Protection Agency (EPA). 1994. Reregistration Eligibility Decision (RED) Limonene.

Suspected of causing cancer

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Causes severe skin burns and eye damage

Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Known to cause cancer

some

California OEHHA (Office of Environmental Health Hazard Assessment): Proposition 65 List (2020 Update)

Carcinogenic to humans

some

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

Known To Be Human Carcinogen

some

National Toxicology Program (NTP): NTP 14th Report on Carcinogens

Probably carcinogenic to humans

some

Environmental Protection Agency (EPA): EPA Integrated Risk Information System (IRIS) - Cancer

This peer-reviewed study reports this substance causes occupational asthma.

some

Fabrizio Guarneri, Olga Barbuzza, Mario Vaccaro & Giuseppe Galtieri. 2008. Allergic contact dermatitis and asthma caused by limonene in a labourer handling citrus fruits. Contact dermatitis 58(5), 315-6.

Toxic if swallowed

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Toxic in contact with skin

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Toxic if inhaled

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

skin irritation

some

U.S. Environmental Protection Agency (EPA). 1994. Reregistration Eligibility Decision (RED) Limonene.

Causes nasal cancer

some

Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards

Generally accepted as an asthmagen.

some

Association of Occupational and Environmental Clinics (AOEC): AOEC Exposure Code List (2020 Update)

suspected human carcinogen

some

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

May cause an allergic skin reaction

Only in: Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

European Union Ecolabel program data shows this substance has high acute toxicity to aquatic life

some

EU Ecolabel: Detergents Ingredients Database

Causes severe skin burns and eye damage

Only in: Drain Opener/Clog Remover; Oven Cleaner; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners

some

EU GHS Hazard Labeling Codes: GHS Hazard Codes

Causes respiratory irritation

some

Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards

Causes skin irritation

some

Centers for Disease Control and Prevention (CDC): NIOSH Pocket Guide to Chemical Hazards

May cause an allergic skin reaction

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

NTP Toxcast scored 1.5-2.5

some

National Toxicology Program (NTP): EWG Toxcast Analysis

causes serious eye irritation

Only in: Household Cleaners

some

European Chemicals Agency (ECHA): GHS Data from ECHA Website

Not classifiable as to its carcinogenicity to humans

low

International Agency for Research on Cancer (IARC): Agents classified by the IARC Monographs (through Volume 127)

eye irritation

low

American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Value (TLV) Basis

EPA testing shows this substance has moderate acute toxicity to aquatic life

low

Environmental Protection Agency (EPA): EPA Fathead Minnow Acute Toxicity Database

The European Union Ecolabel program reports this substance is readily biodegradable.

low

EU Ecolabel: Detergents Ingredients Database

This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration

Only in: Household Cleaners

low

U.S. Food and Drug Administration (FDA): FDA - Priority based Assessment of Food Additive (PAFA)

A review article reports that terpenes may have anticancer properties.

low

Girija Kuttan, Poyil Pratheeshkumar, Kanjoormana Aryan Manu & Ramadasan Kuttan. 2011. Inhibition of tumor progression by naturally occurring terpenoids. Pharmaceutical biology 49(10), 995-1007.

developmental and reproductive toxicity

low

U.S. Environmental Protection Agency (EPA). 1994. Reregistration Eligibility Decision (RED) Limonene.

mutagenicity and/or DNA damage

low

U.S. Environmental Protection Agency (EPA). 1994. Reregistration Eligibility Decision (RED) Limonene.



Understanding scores

EWG provides information on cleaning product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any.

HOW WE DETERMINE SCORES

Hazard score

The Healthy Cleaning ingredient hazard score, from A to F, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend


4

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