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C

CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT

 
Asthma/Respiratory
 
Some Concern
 
Skin Allergies &
Irritation
 
Some Concern
 
Developmental &
Reproductive Toxicity
 
No Data, Some Concern
 
Cancer
 
Some Concern
 
Environment
 
Some Concern
 
Top scoring factors: Evidence of acute aquatic toxicity; skin irritation/allergies/damage; respiratory effects
CITRUS GRANDIS (GRAPEFRUIT) SEED EXTRACT can be found in 28 products.
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Evidence

Health issue
 
Level of Concern
 
Source
Known to cause cancer
 
high
 
Prop 65 - CA Proposition 65
The European Food Safety Authority reports this substance causes reproductive effects in animals.
Only in: Food
 
high
 
European Food Safety Authority. 2004. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). EFSA-Q-2004-063.
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
 
moderate
 
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
The European Food Safety Authority reports this substance causes hyperplasia in animals at high doses.
 
moderate
 
European Food Safety Authority. 2004. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). EFSA-Q-2004-063.
Component: D-LIMONENE
EPA testing shows this substance has high acute toxicity to aquatic life
 
some
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
Component: D-LIMONENE
Recognized by the European Union as a skin allergen
 
some
 
Allergen list - EU Cosmetics Directive
Component: D-LIMONENE
This peer-reviewed study reports this substance causes occupational asthma.
 
some
 
Fabrizio Guarneri, Olga Barbuzza, Mario Vaccaro & Giuseppe Galtieri. 2008. Allergic contact dermatitis and asthma caused by limonene in a labourer handling citrus fruits. Contact dermatitis 58(5), 315-6.
Component: D-LIMONENE
Not classifiable as to its carcinogenicity to humans
 
low
 
IARC 103 - IARC
Component: D-LIMONENE
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
A review article reports that terpenes may have anticancer properties.
 
low
 
Girija Kuttan, Poyil Pratheeshkumar, Kanjoormana Aryan Manu & Ramadasan Kuttan. 2011. Inhibition of tumor progression by naturally occurring terpenoids. Pharmaceutical biology 49(10), 995-1007.
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
 
low
 
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
The European Food Safety Authority reports this substance is not gentoxic
Only in: Food
 
low
 
European Food Safety Authority. 2004. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219). EFSA-Q-2004-063.

Impurities

Health issue
 
Level of Concern
 
Source
Impurity: DIOXINS
Known to cause reproductive toxicity
 
some
 
Prop 65 - CA Proposition 65
Impurity: FORMALDEHYDE
Suspected of causing cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: FORMALDEHYDE
Known to cause cancer
 
some
 
Prop 65 - CA Proposition 65
Impurity: DIOXINS
Clear evidence of endocrine disruption in at least one animal study
 
some
 
EU Endocrine Disrupters - EU Endocrine
Impurity: FORMALDEHYDE
Causes severe skin burns and eye damage
Only in: Oven Cleaner; Drain Opener/Clog Remover; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: TRICLOSAN
Very toxic to aquatic life with long lasting effects
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: DIOXINS
Known To Be Human Carcinogen
 
some
 
NTP 12th RoC - National Toxicology Program (NTP)
Impurity: METHYLPARABEN
Clear evidence of endocrine disruption in at least one animal study
 
some
 
EU Endocrine Disrupters - EU Endocrine
Impurity: FORMALDEHYDE
Carcinogenic to humans
 
some
 
IARC 103 - IARC
Impurity: FORMALDEHYDE
Known To Be Human Carcinogen
 
some
 
NTP 12th RoC - National Toxicology Program (NTP)
Impurity: DIOXINS
Carcinogenic to humans
 
some
 
IARC 103 - IARC
Impurity: DIOXINS
Known to cause cancer
 
some
 
Prop 65 - CA Proposition 65
Impurity: CHLOROFORM
Known to cause cancer
 
some
 
Prop 65 - CA Proposition 65
Impurity: CHLOROFORM
Known to cause reproductive toxicity
 
some
 
Prop 65 - CA Proposition 65
Impurity: CHLOROFORM
Suspected of causing cancer
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: TRICLOSAN
Very toxic to aquatic life
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CHLOROFORM
Probably carcinogenic to humans
 
some
 
EPA Integrated Risk Information System (IRIS) - Cancer - Environmental Protection Agency (EPA)
Impurity: FORMALDEHYDE
Probably carcinogenic to humans
 
some
 
EPA Integrated Risk Information System (IRIS) - Cancer - Environmental Protection Agency (EPA)
Impurity: CHLOROFORM
Reasonably Anticipated To Be Human Carcinogen
 
some
 
NTP 12th RoC - National Toxicology Program (NTP)
Impurity: FORMALDEHYDE
Toxic in contact with skin
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: FORMALDEHYDE
Toxic if swallowed
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: FORMALDEHYDE
Toxic if inhaled
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CHLOROFORM
central nervous system impairment
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: CHLOROFORM
embryo/fetal damage
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: FORMALDEHYDE
Causes nasal cancer
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: FORMALDEHYDE
Generally accepted as an asthmagen
 
some
 
AOEC Asthmagen list - AOEC
Impurity: CHLOROFORM
liver damage
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: METHYLPARABEN
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows concern for reproductive toxicity.
 
some
 
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: FORMALDEHYDE
suspected human carcinogen
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: CHLOROFORM
Harmful if swallowed
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: CHLOROFORM
Possibly carcinogenic to humans
 
some
 
IARC 103 - IARC
Impurity: CHLOROFORM
May cause damage to organs through prolonged or repeated exposure
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: FORMALDEHYDE
Asthmagen
 
some
 
AOEC Asthmagen list - AOEC
Impurity: TRICLOSAN
This review article reports triclosan can act as an endocrine disruptor
 
some
 
Andrea B. Dann & Alice Hontela. 2011. Triclosan: environmental exposure, toxicity and mechanisms of action. Journal of applied toxicology : JAT 31(4), 285-311.
Impurity: TRICLOSAN
European Union Ecolabel program data shows this substance has very high acute toxicity to aquatic life
 
some
 
Detergents Ingredients Database - EU Ecolabel
Impurity: TRICLOSAN
risk of promoting bacterial resistance
 
some
 
Gilles Bedoux, Benoit Roig, Olivier Thomas, Virginie Dupont & Barbara Le Bot. 2012. Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environmental science and pollution research international 19(4), 1044-65.
Impurity: TRICLOSAN
risk of developing antimicrobial-resistant bacteria
 
some
 
Allison E. Aiello, Elaine L. Larson & Stuart B. Levy. 2007. Consumer antibacterial soaps: effective or just risky?. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 45 Suppl 2, S137-47.
Impurity: TRICLOSAN
European Union Ecolabel program data shows this substance has high chronic toxicity to aquatic life
 
some
 
Detergents Ingredients Database - EU Ecolabel
Impurity: METHYLPARABEN
The European Union Ecolabel program reports this substance is not anaerobically degradable.
 
some
 
Detergents Ingredients Database - EU Ecolabel
Impurity: CHLOROFORM
confirmed animal carcinogen with unknown relevance to humans
 
some
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: FORMALDEHYDE
May cause an allergic skin reaction
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: TRICLOSAN
decreases thyroid hormone levels
 
some
 
Katie B. Paul, Joan M. Hedge, Michael J. Devito & Kevin M. Crofton. 2010. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats. Toxicological sciences : an official journal of the Society of Toxicology 113(2), 367-79.
Impurity: TRICLOSAN
triclosan affected estrogen-mediated responses and suppressed thyroid hormone
 
some
 
Tammy E. Stoker, Emily K. Gibson & Leah M. Zorrilla. 2010. Triclosan exposure modulates estrogen-dependent responses in the female wistar rat. Toxicological sciences : an official journal of the Society of Toxicology 117(1), 45-53.
Impurity: TRICLOSAN
A peer-reviewed study reports that triclosan impairs cardiac and skeletal muscle function.
 
some
 
Gennady Cherednichenko, Nipavan Chiamvimonvat, Kurt G. Beam, Bruce D. Hammock, Nils H. Schebb, Genaro C. Barrientos, Wei Feng, Erika B. Fritsch, Ning Li, Valeriy Timofeyev, Roger A. Bannister, Rui Zhang & Isaac N. Pessah. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proceedings of the National Academy of Sciences of the United States of America 109(35), 14158-63.
Impurity: TRICLOSAN
decreases thyroid hormone levels
 
some
 
Katie B. Paul, Joan M. Hedge, Ruby Bansal, R. Thomas Zoeller, Robert Peter, Michael J. Devito & Kevin M. Crofton. 2012. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: Dynamic and kinetic evaluation of a putative mode-of-action. Toxicology.
Impurity: TRICLOSAN
alters endocrine function in a variety of species
 
some
 
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
Impurity: FORMALDEHYDE
European Union Ecolabel program data shows this substance has high acute toxicity to aquatic life
 
some
 
Detergents Ingredients Database - EU Ecolabel
Impurity: TRICLOSAN
Triclosan may negatively affect immune function in people
 
some
 
Erin M. Rees Clayton, Megan Todd, Jennifer Beam Dowd & Allison E. Aiello. 2011. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006. Environmental health perspectives 119(3), 390-6.
Impurity: TRICLOSAN
alters endocrine function in a variety of species
 
some
 
Leah M. Zorrilla, Emily K. Gibson, Susan C. Jeffay, Kevin M. Crofton, Woodrow R. Setzer, Ralph L. Cooper & Tammy E. Stoker. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicological sciences : an official journal of the Society of Toxicology 107(1), 56-64.
Impurity: CHLOROFORM
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: TRICLOSAN
Causes skin irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: FORMALDEHYDE
Causes severe skin burns and eye damage
Only in: Drain Opener/Clog Remover; Oven Cleaner; Hard Water Stain Remover; Toilet Cleaner; Stove Top Cleaner; Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: FORMALDEHYDE
Causes respiratory irritation
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: TRICLOSAN
NTP Toxcast scored 0.5-1.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
Impurity: FORMALDEHYDE
Causes skin irritation
 
some
 
NIOSH Pocket Guide to Chemical Hazards - Centers for Disease Control and Prevention (CDC)
Impurity: TRICLOSAN
Causes serious eye irritation
Only in: Household Cleaners
 
some
 
GHS Hazard Codes - EU GHS Hazard Labeling Codes
Impurity: METHYLPARABEN
NTP Toxcast scored 0.5-1.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
Impurity: FORMALDEHYDE
NTP Toxcast scored 0.5-1.5
 
some
 
EWG Toxcast Analysis - National Toxicology Program (NTP)
Impurity: FORMALDEHYDE
eye irritation
 
low
 
Threshold Limit Value (TLV) Basis - American Conference of Governmental Industrial Hygienists (ACGIH)
Impurity: CHLOROFORM
EPA testing shows this substance has moderate acute toxicity to aquatic life
 
low
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
Impurity: METHYLPARABEN
European Union Ecolabel program data shows this substance has moderate acute toxicity to aquatic life
 
low
 
Detergents Ingredients Database - EU Ecolabel
Impurity: FORMALDEHYDE
EPA testing shows this substance has moderate acute toxicity to aquatic life
 
low
 
EPA Fathead Minnow Acute Toxicity Database - Environmental Protection Agency (EPA)
Impurity: TRICLOSAN
The European Union Ecolabel program reports this substance in inherently biodegradable.
 
low
 
Detergents Ingredients Database - EU Ecolabel
Impurity: METHYLPARABEN
This substance is Generally Recognized as Safe (GRAS) as a food additive by the US Food and Drug Administration
Only in: Household Cleaners
 
low
 
FDA - Priority based Assessment of Food Additive (PAFA) - U.S. Food and Drug Administration (FDA)
Impurity: FORMALDEHYDE
The European Union Ecolabel program reports this substance is readily biodegradable.
 
low
 
Detergents Ingredients Database - EU Ecolabel
Impurity: METHYLPARABEN
The EU Scientific Committee on Consumer Products (SCCP) reports that this substance shows no concern for reproductive toxicity.
 
low
 
SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS. 2005. SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS (SCCP) Extended Opinion on the Safety Evaluation of Parabens.
Impurity: METHYLPARABEN
The European Union Ecolabel program reports this substance is readily biodegradable.
 
low
 
Detergents Ingredients Database - EU Ecolabel
 
 
About the ratings About the ratings
EWG provides information on cleaning product ingredients from the published scientific... continue reading →
EWG provides information on cleaning product ingredients from published scientific literature, to supplement incomplete data available from companies and the government. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors that determine actual health risks, if any. (Hide)
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